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Meta Roestenberg on Muck Rack

Meta Roestenberg

As seen in: Nature, BMJ Open, Science Magazine, BioRxiv, Cell Press, The Lancet
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Articles

Artificial intelligence powered decoding of Plasmodium falciparum sporozoite motility patterns

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By Kateryna Pirkovets, Meta Roestenberg, Chanel Milène Naar, Clarize M. de Korne, Roos van Schuijlenburg
| Nature Verified
Abstract Sporozoites (SPZ), the infective mosquito stage of Plasmodium falciparum malaria, are widely studied as therapeutic targets for antibodies either endogenously induced by vaccines or administered as exogenous monoclonal antibody treatment. The unicellular protozoa are highly motile and adapted to migrate through tissues, facilitating the transition from mosquito-based skin inoculation to the infection of hepatocytes in the liver.
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Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review

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By Angela van Diepen, Meta Roestenberg, Instituto Butantan, Batavia Biosciences BV
| BioRxiv
Abstract Background Schistosomiasis is a neglected tropical disease caused by infection with worms of genus Schistosoma including S. mansoni. Over 200 million people are infected, sterile immunity does not naturally develop, and no vaccine is available. A vaccine could be a critical tool to achieve control and elimination. Numerous candidates have been tested in pre-clinical models, but there is not yet an approved vaccine.
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Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial | Nature Medicine

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By Meta Roestenberg
| Nature Verified
Abstract Malaria vaccines consisting of metabolically active Plasmodium falciparum (Pf) sporozoites can offer improved protection compared with currently deployed subunit vaccines. In a previous study, we demonstrated the superior protective efficacy of a three-dose regimen of late-arresting genetically attenuated parasites administered by mosquito bite (GA2-MB) compared with early-arresting counterparts (GA1-MB) against a homologous controlled human malaria infection.
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