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Meta Roestenberg on Muck Rack

Meta Roestenberg

As seen in: Nature, BMJ Open, Science Magazine, BioRxiv, Cell Press, The Lancet
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Articles

Heritable transgenic schistosomes as a living platform for SARS-CoV-2 neutralizing antibody secretion

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By Wannaporn Ittiprasert, Michael J Smout, Victoria Mann, Matthew Moyle, Sean M Kinahan, Daniel Ackerman, Danielle N Rivera, Joshua L Santarpia, Eric Carnes, Margaret M. Mentink-Kane, Cornelis H. Hokke, Meta Roestenberg, Maria Elena Bottazzi, Bethany Bracken, Bruce A. Rosa, Sergej Djuranovic, Darren A. Pickering, Paul Giacomin, Daniel Watterson, Naphak Modhiran, Max F Moescheid, Christoph G Grevelding, Makedonka Mitreva, Alex Loukas, Paul J. Brindley
| Nature Verified
Abstract We report the generation and propagation of not only the first heritable transgenic schistosome line but also a line that secretes a functional therapeutic protein in vivo. Using multiplexed CRISPR/Cas-mediated homology-directed knock-in targeted to a predicted genomic safe-harbor, we inserted a VHH–IgG1 Fc (termed C5-Fc) transgene into Schistosoma mansoni eggs.
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Artificial intelligence powered decoding of Plasmodium falciparum sporozoite motility patterns

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By Kateryna Pirkovets, Meta Roestenberg, Chanel Milène Naar, Clarize M. de Korne, Roos van Schuijlenburg
| Nature Verified
Abstract Sporozoites (SPZ), the infective mosquito stage of Plasmodium falciparum malaria, are widely studied as therapeutic targets for antibodies either endogenously induced by vaccines or administered as exogenous monoclonal antibody treatment. The unicellular protozoa are highly motile and adapted to migrate through tissues, facilitating the transition from mosquito-based skin inoculation to the infection of hepatocytes in the liver.
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Pre-clinical studies of Schistosoma mansoni vaccines: a scoping review

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By Angela van Diepen, Meta Roestenberg, Instituto Butantan, Batavia Biosciences BV
| BioRxiv
Abstract Background Schistosomiasis is a neglected tropical disease caused by infection with worms of genus Schistosoma including S. mansoni. Over 200 million people are infected, sterile immunity does not naturally develop, and no vaccine is available. A vaccine could be a critical tool to achieve control and elimination. Numerous candidates have been tested in pre-clinical models, but there is not yet an approved vaccine.
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