Metabolic Imaging

BOLD blood oxygenation level dependent CBF cerebral blood flow CBV cerebral blood volume CNS central nervous system dDNP dissolution dynamic nuclear polarization fMRI functional MRI fMRS functional MRS LFP local field potential MABP mean arterial blood pressure MCT monocarboxylate transporter nAChR nicotine acetylcholine receptor NaOH sodium hydroxide SD standard deviation TE echo time INTRODUCTION Functional MRI (fMRI) is one of the most well established pre-clinical and clinical research...

The SUVr in STZ rats was reduced in multiple brain regions as compared to CTL, confirming the locally impaired glucose metabolism (Fig. 3). Glucose hypometabolism concerned mainly DMN and LCN regions. Differences were present across time, with the most widespread changes occurring at 6 weeks after icv injection. Group differences in SUVr at each timepoint. Green: ROIs with significantly lower SUVr in STZ (p < 0.05 using one-tailed Mann–Whitney U test, STZ < CTL).

Diane Macabrey Diane Macabrey Correspondence Corresponding author Affiliations Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, SwitzerlandDepartment of Biomedical Sciences, University of Lausanne, Switzerland Search for articles by this author Jaroslava Joniová Jaroslava Joniová Affiliations Laboratory for Functional and Metabolic Imaging, LIFMET, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland Search for articles by this author Alban...