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Metabolomics Core

As seen in: Nature, Oxford University Press (OUP), Frontiers, Molecular Cancer, Cell Chemical Biology, Cell Press
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Articles

Effects of GDF6 on active protein synthesis by cells of degenerated intervertebral disc - European Spine Journal

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By Hong Kong S.A.R, Metabolomics Core
| link.springer.com
Abstract Intervertebral disc degeneration (IVD) is a leading cause of low back pain, a prevalent musculoskeletal condition. IVD degeneration is characterized by the degradation of nucleus pulposus (NP), annulus fibrosus (AF), and cartilage endplates (EP). Growth Differentiation Factor 6 (GDF6), part of the bone morphogenetic protein family, has demonstrated potential in maintaining disc integrity. However, its precise role in cellular protein synthesis during IVD degeneration remains unclear.
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Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer | Molecular Cancer | Full Text

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By Babal Kant, J. Mark, Microbiome Analytics, Metabolomics Core
| Molecular Cancer Verified
Cancer cells and others, CP70 (Culture media: DMEM 10% FBS), A2780 (Culture media DMEM: 10% FBS), SKOV3 (Culture media: McCoy5a 10% FBS), TOV112D (Culture media: MCDB 15% FBS), OVCAR8 (Culture media: DMEM 10% FBS), OV81 (Culture media: DMEM 10% FBS), HEK293T (Culture media: DMEM 10% FBS), Jurkat (Culture media: RPMI 10% FBS) cells were grown in recommended growth media in humidified incubator containing 5% CO2.
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Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer | Molecular Cancer

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By J. Mark, Metabolomics Core, Babal Kant, Microbiome Analytics
| link.springer.com
Abstract Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our previous studies identified cell surface CD55, a member of the complement regulatory proteins, drives chemoresistance and maintenance of cancer stem cells (CSCs). CSCs are implicated in tumor recurrence and metastasis in multiple cancers.
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