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Articles by Michael Carty
Canonical and Non-Canonical Roles of Human DNA Polymerase η
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Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity
1 Introduction Interleukin (IL)-1β is a key inflammatory cytokine that has a broad activity causing fever, inducing acute-phase proteins, and recruiting and activating immune cells (1). IL-1β can be released in response to infection but has also been associated with the pathogenesis of many sterile inflammatory diseases, including gout, type 2 diabetes and rheumatoid arthritis (1–3).
Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis
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Benchmarking Thermodynamic Models for Optimization of PSA Oxygen Generators
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Michael L. Carty 1 and Stephane Bilodeau 1,2,* 1 Smart Phases Inc., Plattsburgh, NY 12903, USA 2 Department of Bioengineering, McGill University, Montreal, QC H3A 0B9, Canada * Author to whom correspondence should be addressed.
New life emerging
How do you perceive the present moment? You can sometimes see in the present moment both the fading of the world that came before and the new life that will take its place emerging. Do you live in the past? Is your head always dreaming of, plotting for, or even just plain dreading the future? Do you believe that the present moment is all there is? There is no right or wrong answer to any of the above questions. Just as there is no right or wrong way to perceive the passage of time.
Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1
1 Introduction Many of the cellular effects of reactive oxygen species (ROS) are due to oxidation of the base composition of DNA. Among the DNA bases, the most susceptible base to oxidation is guanine (Gua). The generated 8-oxo-7,8-dihydroguanine (8-oxoGua) is a marker of oxidative stress intensity (1). 8-oxoGua is repaired through the evolutionally conserved base excision repair (BER) pathway (2), which is primarily initiated by 8-oxoguanine DNA glycosylase/lyase 1 (OGG1) (3).
Never give 100%?
Is constantly giving our all – always seeing 100% as the bare minimum – the wisest or most sustainable approach to life and to work? Gentle reader: How are you approaching life and all its challenges in 2023? What’s your level of drive and commitment as you throw yourself into your life and work? I would hazard a guess that most people reading these words will be giving around or above 100%, in all directions, at all times. Life never lets up. We feel such guilt if we have not given our all.
The sun will return
The sun will return. No matter how dark the night. No matter how dark the mood. No matter how dark the moment. The sun will return. My good friend Dean Royles is sunshine personified. If you know Dean, you will already know what I mean. If you don’t yet know him, please do consider following him on Twitter. The other day I had the pleasure of a long overdue video catch-up with the great gent. At one point, we got to talking about my mental health situation.
Mastodon FAQ: Toot sweet?
Mastodon: the next big thing in social media? Here, I attempt to answer some frequently asked questions for new Mastodon users or the Mastodon-curious. Are you on Mastodon? What does the word “toot” mean to you? Is Mastodon worth your time? Mastodon is rapidly growing right now, with an influx of users from Twitter and other social media (including the wonderful Stephen Fry, who also deleted his Twitter account this past week). But Mastodon is not a direct replacement for Twitter.
Brevity
Brevity is next to godliness. There is tremendous power in making your case with the fewest – but best chosen – words possible. “Nobody has ever said of any presentation: it was great but too short.” So wrote Sathnam Sanghera (author of the excellent Empireland) in a 2006 FT article entitled Why brevity is always best. Even then, brevity was something of a delicious luxury.
Coping?
Gentle reader: How are you coping with all that you are going through, right now? If you feel like you need help, never be afraid to seek it. I sincerely hope that these words find you in good spirits and even better health, and that you feel you are coping as well as can be with each challenge that life has decided to place as an obstacle in your path. If you feel that you are coping, then you are doing well. If that is all that you have in life, then life cannot be entirely bad.
Equality, diversity and inclusion: XpertHR survey 2022
This is a preview. To continue reading, register for free access now. Register now or Log in Author: Michael Carty XpertHR research provides data on how UK employers approach equality, diversity and inclusion in the workplace. Already an XpertHR user? Log in
Give good thank you
Gratitude has immense power. Give good thank you to all you meet today. Life is all too often a hair-tearingly frustrating maze. The path through to the other side might seem impossibly convoluted, the prize that may or may not be waiting for you unreachable. When you are lost in the maze, just hearing the simplest words -if brusque, impatient, or mindless – can make everything 10 times worse. Discouragement is real. And often both unnecessary and avoidable.
The Palin principle
Michael Palin’s diaries from 50 years ago this month paint an oddly familiar picture of a time of energy crisis, “non-government” and an underlying absurdity and silliness. “Driving home has become quite an adventure now, for with the power-cuts I never know which traffic lights will be working and which won’t.
Effective actions to boost diversity and inclusion in recruitment
With businesses facing close scrutiny over the actions they take to improve diversity and inclusion (D&I), recruitment practices have an important part to play. With businesses facing close scrutiny over the actions they take to improve diversity and inclusion (D&I), recruitment practices have an important part to play. How and whom organisations recruit and retain provides a direct and visible demonstration of how seriously the organisation takes D&I.
Fall away
Everything will fall away with time. Each year, autumn gives us a small taste of this eternal truth. Autumn is profoundly beautiful in its own way. All the leaves are brown? Check. And the sky is grey? Affirmative. Summer with all its warmth and light was here. Now let it fall away. Things have felt more than a little Mamas & the Papas* these past few days. And it is not even as yet such a winter’s day. Autumn has set up shop in a manner most unambiguous. Summer 2021 in the UK barely felt like it got going.
Recruitment showing signs of recovery, but challenges persist
Contributor: Michael Carty | Published: 9 September 2021 Michael Carty 8 September 2021 Latest data* shows that the UK recruitment market is showing strong signs of recovery from the disruption posed by the pandemic, yet significant challenges remain, with skills shortages and finding the right talent proving acute for many organisations.
The beautiful struggle
What lies ahead always appears daunting. But we can still love (or learn to love) the struggle, the beautiful struggle that lasts exactly as long as life does. “I love how being an adult is just saying “But after this week things will slow down a bit again” to yourself until you die.” This might just be the perfect definition of life as a grown-up. I chanced upon it the other week via atweet from the lovely Laurie Ruettimann.
Equality is fragile
We can never take equality for granted. Any progress towards equality is always at risk of being reversed. Prejudice will always find new forms. I sometimes wonder if I deserve to live in the same world as Sue Perkins.
Many lifetimes, days and confused
Life will never remain just one thing. You don’t have have to remain just one thing. This is one of life’s greatest gifts to each of us. “You have many lifetimes in this one lifetime, Marc. Don’t get stuck on that identity.” I’ve always loved these words from Rupaul’s 2014 appearance on Marc Maron’s WTF podcast. They capture perfectly and succinctly the ever changing nature of life, and the choice that we can all make to change with it. This is one of life’s greatest gifts. Reinvention is real.
Living in two worlds
When you find yourself living in two worlds, embrace the new world that is manifesting around you. “It was the sort of early summer evening in New York when all you can think of is living… Everything was as it should be, except that it wasn’t. We were living in two worlds.
Sketchtober ONE (Life’s a bony cabaret!)
Welcome to Sketchtober! I’m doing a brand-new ink drawing for every day of October 2020. This first round-up of my daily Sketchulence finds Mr Skeleton channelling Liza in a rather fabulous manner. This year I’m going with Sketchtober for my October daily drawing challenge (the previously popular hashtag having reportedly proven problematic*). All this month, I’m going to be “debuting” each day’s picture on Instagram, then rounding them up with a weekly gallery post here on MJCarty.com.
We’re all beginners at this
Are we just beginning to feel the true impact of the hard reset to our lives that has been forced by the pandemic? Life’s eternal trick is the surprise that comes around with such regularity that the only truly surprising thing is how it never ceases to surprise. Yet somehow it always seems to creep up and put you right back at the beginning. Towards the end of each summer, I want to avoid writing that post.
XpertHR benefits and allowances survey 2020: Pension benefits
This is a preview. To continue reading please log in or Register to read this article Author: Michael Carty XpertHR research provides data on UK employers' pensions offerings, including: the types of pension scheme offered to employees; contribution rates and membership; pensions auto-enrolment arrangements; and systems of matched pension contributions. View the full article today Register to read this article Already an XpertHR user? Log in
My top 5 podcasts of 2020 (Part one)
What are the best podcasts of 2020? My pick of the podcasts that have meant the most to me in the first six months of 2020, featuring: Steve Silberman; David Crosby; Richard Herring; Michael Palin; Shereen Daniels; Rosey Jarvis; Scott Adams; Naval Ravikant; Moodie Black; Myke C-Town; and Chief. I am sure that for anyone and everyone these first six months of 2020 have been something of a rollercoaster. The world is in flux. Change, they say, is the only constant. That feels especially true for 2020.
The not-so-immaculate conception of Basil Fawlty
How can we tell when genius strikes? Exactly 39 years ago this week (on Friday 19 September 1975), the very first episode of Fawlty Towers was broadcast. And if anything can safely be said to define the word “genius,” it’s Fawlty Towers. In the case of the creation of Basil Fawlty, we have that rarest of luxuries. We can pinpoint when genius struck. We know the when, the where, the who, the how and the why.
The not-so-immaculate conception of Basil Fawlty
BASIL! When was Basil Fawlty created? We can pinpoint the exact date of the not-so-immaculate conception of Basil Fawlty via Michael Palin’s The Python Years: Diaries 1968-1979. How can we tell when genius strikes? On Friday 19 September 1975 the very first episode of Fawlty Towers was broadcast. And if anything can safely be said to define the word “genius,” it’s Fawlty Towers. In the case of the creation of Basil Fawlty, we have that rarest of luxuries. We can pinpoint when genius struck.
Letter informing staff of a recruitment drive because of the coronavirus outbreak
This is a preview. To continue reading please log in or Register to read this article Original author: Michael Carty When to use this model coronavirus/recruitment letter Use this model HR letter to notify employees that your organisation is launching a recruitment drive because of the coronavirus (COVID-19) outbreak. View the full article today Register to read this article Already an XpertHR user? Log in
People analytics and HR lead the way through the coronavirus pandemic
This is a preview. To continue reading please log in or Register to read this article Author: Michael Carty The People Analytics and Future of Work (PAFOW) conference profiled initiatives that are helping organisations around the world use data to deal with workforce issues caused by the coronavirus (COVID-19) pandemic. View the full article today Register to read this article Already an XpertHR user? Log in
Heroes just for one day?
We could be heroes. Just for one day? The coronavirus pandemic raises questions about how we treat those we call heroes at the frontline of the crisis. Doctors, nurses, care workers, retail staff, and so many more. All those who find themselves on the frontline of the coronavirus pandemic deserve our applause. They deserve so much more than our applause. How do we honour our heroes? Is heroism the most thankless calling?
Letter notifying staff of a recruitment freeze because of the coronavirus outbreak
This is a preview. To continue reading please log in or Register to read this article Original author: Michael Carty When to use this model coronavirus/recruitment letter Use this model HR letter to notify employees that your organisation is freezing its recruitment activities in response to the coronavirus (COVID-19) outbreak. View the full article today Register to read this article Already an XpertHR user? Log in
Ready to imagine another world
What do you want the post-pandemic world to look like? This post is inspired by wise words and thoughts from Arundhati Roy, Naval Ravikant and Scott Adams. Within just a few weeks, everything has changed. The coronavirus pandemic is a black hole that has sucked in all of our lives, all of our thoughts. “Who can think of kissing a stranger, jumping on to a bus or sending their child to school without feeling real fear?
Letter awarding staff a bonus during the coronavirus outbreak
This is a preview. To continue reading please log in or Register to read this article Original author: Michael Carty When to use this model coronavirus/bonus letter Use this model HR letter to advise employees that they are receiving a bonus payment during the coronavirus (COVID-19) outbreak. View the full article today Register to read this article Already an XpertHR user? Log in
Letter outlining flexibility for employees with caring responsibilities who are working from home during the coronavirus outbreak
This is a preview. To continue reading please log in or Register to read this article Original author: Michael Carty When to use this model coronavirus letter Use this model letter to set out your approach to enabling employees who have caring responsibilities to work flexibly while they are working from home during the coronavirus (COVID-19) outbreak. View the full article today Register to read this article Already an XpertHR user? Log in
Farewell, Lord Sabre (Andrew Weatherall RIP)
Andrew Weatherall’s death was a truly jolting moment, the saddest of losses. This post is my personal tribute to this musical maverick, this genius gentleman raconteur. I am also honoured to host Tim Scott’s tribute to Lord Sabre. Gentle reader: What was the first death of a famous person that truly shocked you?* For me, it was the passing of John Peel**, on 25 October 2004. A cold, jolting shock. The abrupt snuffing of an eternal, comforting yet radically transformative light. The most tragic loss.
David Crosby: Fighting darkness, shedding light
Freak Flag Flying – David Crosby’s epic podcast conversation with Steve Silberman – is a beautiful gift to humanity, generously sharing warmth, wisdom and wonderful music. “I was fighting darkness, so I was shedding a lot of light.” These words are spoken by David Crosby in the fourth episode of Freak Flag Flying, an epic podcast conversation with his close friend Steve Silberman. Crosby is describing the personal struggles he endured while making If I Could Only Remember My Name.
Michael Palin’s beautiful friendship with Terry Jones
Sir Michael Palin’s words about the dearly departed Terry Jones are the simplest and most beautiful tribute to true friendship. How endlessly sustaining and enriching is true friendship. A simple, mutual joy in one another’s company. True friendship can feel eternal, as though you and your friend have always known one another. As though they will always be there for you, and you for them. Then mortality intervenes. How irreplaceable is true friendship when it is lost.
My top 5 podcasts of 2019
My pick of the podcasts that have meant the most to me in 2019, featuring: Scott Adams; Naval Ravikant; Richard Herring; Samira Ahmed; Brian Koppelman; Joe Rogan; Michael Rapaport; Rich Roll; Jocko Willink; Kate Carrau; and Adam Buxton. Podcasting keeps going from strength to strength. Voices of wit and wisdom, voices I love. Podcasts have gifted me an embarrassment of riches in 2019. I can’t wait to hear what comes next.
A year in the life of Emma Dixon: No fear but only love
I am honoured to host a guest post from Emma Dixon – human rights barrister, end of life doula in training, and a wonderful human being. Emma has written some wonderful words about her experiences in 2019 and the lessons that she has taken from them. I would like to thank Emma for so generously penning such a rich, moving and ultimately joyous and inspirational post. Please consider following Emma on Twitter and Instagram.
Essential HR metrics for 2020
Graphic Farm/Shutterstock With data skills increasingly critical for success in the HR profession, new analysis from XpertHR reveals three priority areas for HR metrics data activities in 2020. “The future of the HR profession lies in analytics.” This is according to Fermin Diez, Mark Bussin and Venessa Lee, authors of “Fundamentals of HR analytics”, a book providing practical guidance on using data to inform and improve HR policies and practices.
#FiveQuidFoodBank
The #FiveQuidFoodBank campaign encourages people to donate £5 to their local food bank, or directly to the Trussell Trust. Russ Jones – who originated #FiveQuidFoodBank in 2017 – explains how #FiveQuidFoodBank came to be, and why it’s just as necessary today. Where is your next meal coming from? I can probably count on one hand the number of times the TV news has moved me to tears. The latest was earlier this month. I was watching a BBC News item on the rapid rise in food bank usage in the UK.
My top 5 podcasts of 2019 (so far!) Part III
My third pick of the podcasts that have meant the most to me in 2019 (so far!), featuring: Laurie Ruettimann; Rich Roll; Jeff Gordinier; Richard Herring; Tony Slattery; Joey Diaz; Andrew Schulz; RuPaul; Michelle Visage; Nile Rodgers; Leonard Maltin; Jessie Maltin; and Fred Willard. What podcasts have spoken to you this year? What podcasters go deep into your skull?
My #Inktober training montage
A selection of #Sketchulence from recent weeks, as I gear up for this year’s #Inktober challenge. Gentle reader: I was a little lax on the drawing front over the summer. With the annual #Inktoberchallenge (share an ink drawing each day throughout October) on the horizon, I think it’s high time to get in training. (Cue Rocky training montage music). What do you do when you’re feeling creatively stuck or don’t know where to start? For me, I find it’s best to clear your mind and start anywhere.
A touch of chaos in the air
Inspired by his travels with Noma chef René Redzepi, Jeff Gordinier’s Hungry is a feast of insight and wisdom on risk and chaos, creativity and reinvention, leadership and excellence. “Sometimes it’s good to brush up against the possibility of losing everything.” So writes Jeff Gordinier in Hungry, his book about his time spent with René Redzepi – the “greatest chef in the world”. Redzepi is all about constant reinvention.
Walk out a different person
When was the moment your life changed? If you open your senses to them, moments of synchronicity can usher in profound change, or simply render the present moment magical. Gentle reader: Might I make a guess about you? The path to where you are in life was more than likely an unlikely one. The you that is reading this could so easily have been so very different. Say you’d not met that one person, not made that one decision, not been in that one place at that one moment, all those years ago.
Blogaversary time! Celebrating MJCarty.com’s 1st year
MJCarty.com celebrates its first birthday this week! Here are some words on why I love to write this blog, plus a quick flit through the most-read posts from the first year of MJCarty.com. Time flies when you are up in the clouds. The other week, I met my friend Kate Griffiths-Lambeth for a lunch to celebrate what must be almost a decade of friendship.
The Skeleton Collection: My debut postcard set!
I am delighted to announce the launch of my debut Skeleton postcard collection: A set of three pictures of Mr Skeleton living his best #SkeleLife, available to buy right now! Gentle reader: These past few months, my #Sketchulence has taken a distinct turn for the bony. I have greatly enjoyed drawing the ongoing adventures of the good Mr Skeleton. It all kicked off with this picture – both my first-ever experiment with single-line doodling and my first ever meeting with Mr Skeleton).
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
Highlights • NLRP3 inflammasomes stimulate IL-1β release either with or without cell death • The TIR protein SARM negatively regulates NLRP3 to reduce IL-1β release • SARM-mediated mitochondrial depolarization (MDP) is required for optimal pyroptosis • NLRP3 activators that don’t kill cells fail to cause SARM-dependent MDP Summary Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis.
Bryan Wempen interview: Sober is Better
An interview with Bryan Wempen, whose new book Sober Is Better: My Note to Self talks movingly – and with great warmth and humour – of his life, his experiences of addiction, and his journey of recovery and discovery. “Starting over isn’t a failure; it’s a smarter beginning.” I’ve always loved these words from Bryan Wempen’s first book, Note To Self. We still have a choice. We always have it in us to improve our lives, and how we approach the world. We can always do better for ourselves and others.
Strategic people analytics in action
Michael Carty reports from the People Analytics and Future of Work (PAFOW) conference in London, which explored how people analytics can benefit organisations and the wider community. “We are in an innovative time and space for people analytics.” This is according to Al Adamsen of people analytics specialists Insight222, introducing the April 2019 PAFOW conference.
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