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Michael D. Gambardella on Muck Rack

Michael D. Gambardella

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The Cholinergic Selectivity of FDA-Approved and Metabolite Compounds Examined with Molecular-Docking-Based Virtual Screening

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By Yigui Wang, Michael D. Gambardella, Jiongdong Pang
| MDPI
1. Introduction Acetylcholinesterase (AChE) is a hydrolase enzyme found primarily in the postsynaptic neuromuscular junction and responsible for hydrolyzing the neurotransmitter acetylcholine (Ach) into acetic acid and choline [1]. Ach binds to muscarinic receptors on the postsynaptic neuron, which activates an intracellular G-protein-coupled receptor and leads to the dephosphorylation of guanosine triphosphate into its diphosphate form.
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