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Articles by Michael Dore
Risk Stratification of Acute Pulmonary Embolism: Outcomes in Patients With Intermediate sPESI Scores and Negative Cardiac Biomarkers
1 Introduction Current guidelines recommend consideration of outpatient management for select patients with newly diagnosed PE, incorporating clinical severity scores, clinical judgment, patient preference, and comorbidities [1, 2]. The sPESI ranges from 0 to 6 and was originally validated using a dichotomous framework: sPESI of 0 denotes “low risk,” while sPESI > 0 denotes “high risk” [3, 4]. Since sPESI validation in 2013, two major developments have reshaped PE management.
Precise length and charge segmentation of billion-dalton supramolecular polymers
Editor’s summary Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary A self-capping supramolecular polymerization yielded peptide-containing assemblies with precisely tuned segments that could exceed 30 micrometers in length (about 1 billion Daltons in mass). Dore et al.
Publisher Correction: Unlocking chemical diversity in aptamers with DNA orthogonal barcodes
Correction to: Nature Chemistry https://doi.org/10.1038/s41557-026-02099-5, published online 6 May 2026. In the version of the article initially published, in the table in Fig. 6, all instances of “CH4” should have read “C” and have now been corrected in the HTML and PDF versions of the article. In the online graphical abstract, an additional “G” was originally in the “Alenomer” structure and has now been removed. About this article Saliba, D., Osman, E.A., Elmanzalawy, A. et al.
Unlocking chemical diversity in aptamers with DNA orthogonal barcodes
Abstract Aptamers are a versatile alternative to antibodies as they are smaller, easier to synthesize and less immunogenic. However, while antibodies are composed of 20 chemically diverse amino acids and are established therapeutics, aptamers are composed of only 4 similar nucleobases, thereby limiting their therapeutic potential. Aptamer chemical modifications are restricted to maintain compatibility with enzymatic selection.
Tu1372 MODEL-BASED EVALUATION OF COLORECTAL CANCER SCREENING EFFECTIVENESS: THREE ROUNDS OF MULTITARGET STOOL DNA TESTING VERSUS ONE COLONOSCOPY
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DNA Hierarchical Superstructures from Micellar Units: Stiff Hydrogels and Anisotropic Nanofibers
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly - Nature Communications
Abstract Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein site-specific intramolecular interactions determine overall structure. Proteins then hierarchically assemble into supramolecular polymers such as microtubules, that are robust yet dynamic, constantly growing or shortening to adjust to cellular needs.
Penicillin De-labeling for the Non-Allergist: A Primary Care Clinic
Penicillin allergy testing, while largely performed by allergists, is a standard of care procedure that can be safely performed by non-allergists. We established a scoring system and primary care de-labeling clinic for non-allergists to evaluate and test penicillin allergies.
Responsive Nucleic Acid-Based Organosilica Nanoparticles
Nanomaterials have enormous potential for advancing disease detection, prevention, and treatment. (1−6) Despite past achievements in the preparation of stimuli-responsive nanomaterials, it remains relatively difficult to encode information for specific functions into nanoparticles (NPs) such as the biomolecule recognition and on-demand degradation in the presence of biological agents.
Primary Cardiac Angiosarcoma: Pericardial Erosion and Disseminated Metastasis in a Young Active Duty Man
Affiliations: 1Department of Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia Corresponding Author Tyler King, MD; Department of Medicine, Naval Medical Center Portsmouth, 620 John Paul Jones Cir, Portsmouth, VA 23708; e-mail, . Disclaimer The views expressed in this case report are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government.
Outpatient Primary Care Management of Headaches: Guidelines from the VA/DoD
Am Fam Physician. 2021 Sep ;104(2):316-320. This clinical content conforms to AAFP criteria for CME. See the CME Quiz Questions. Author disclosure: No relevant financial affiliations. Key Points for Practice • Ibuprofen and high-dose acetaminophen improve acute tension-type headaches. Amitriptyline is effective at preventing tension-type headaches after three months of treatment. • Triptans, ibuprofen, naproxen, aspirin, and high-dose acetaminophen are effective treatments for acute migraine.
Failure To Refute Should Be A Defamation Defense
Law360 (March 25, 2021, 4:13 PM EDT) -- Rep. Devin Nunes, R-Calif., has asserted that he has told colleagues, "We should not be talking to the mainstream media." He has then followed his own advice — even in response to requests for comment about allegations he later claims are defamatory.
Diagnostic Imaging: Appropriate and Safe Use
1. Shrank WH, Rogstad TL, Parekh N. Waste in the US health care system. JAMA. 2019;322(15):1501–1509.... 2. Smith-Bindman R, Kwan ML, Marlow EC, et al. Trends in use of medical imaging in US health care systems and in Ontario, Canada, 2000–2016. JAMA. 2019;322(9):843–856. 3. Medpac. Report to the Congress: Medicare payment policy. March 2020. Accessed April 5, 2020. http://medpac.gov/docs/default-source/reports/mar20_entirereport_sec.pdf 4. Caverly TJ, Prochazka AV, Cook-Shimanek M, et al.
Templated synthesis of spherical RNA nanoparticles with gene silencing activity
M. Dore, J. Fakhoury, A. Lacroix and H. Sleiman, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC06994H If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.
The Progressive Increase of Food Waste in America and Its Environmental Impact
Loading metrics Open Access Peer-reviewed Research Article Kevin D. Hall , Juen Guo, Michael Dore, Carson C. Chow Kevin D. Hall, Juen Guo, Michael Dore, Carson C. Chow Published: November 25, 2009 https://doi.org/10.1371/journal.pone.0007940 Figures Abstract Food waste contributes to excess consumption of freshwater and fossil fuels which, along with methane and CO2 emissions from decomposing food, impacts global climate change.
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