Michael Eriksen Benros

Abstract Large-scale mega-analyses of worldwide combined Magnetic Resonance Imaging (MRI) studies have demonstrated brain differences between individuals with mental disorders and controls. However, the potential of large-scale observational studies using population-based clinical MRI data remains unexplored. We analyzed clinical MRI data from 23,545 patients in the Eastern half of Denmark (Capital Region of Denmark and Region Zealand).

Keywords CCR5 CCR5delta32 HIV-1 infection resistance pleiotropy haplotype recombination ancient genomes evolution positive selection immune genes Introduction Humans have been exposed to pathogens over the course of our evolutionary history, and adaptations to them have left numerous signatures in our genomes.1,2,3 In recent years, evidence for selection has been found in genes involved in the development of tolerance against intracellular pathogens and in the inflammatory response against...