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Articles by Michael Hölzel
Core2Edge : a human glioblastoma organoid–brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion
Abstract Glioblastomas function as intricate cellular networks that extend into the surrounding brain tissue, facilitating long-distance communication. This malignant connectivity spans from the tumor core to remote infiltration zones, in support of the concept of glioblastoma as a whole-brain disease.
Longitudinal spatial neutrophil profiling during ACT in murine melanoma reveals distinct lymph node infiltration patterns
Abstract Reactive neutrophil infiltration can restrain CD8+ T cell expansion in lymph nodes during adoptive T cell therapy (ACT), yet its spatiotemporal regulation remains incompletely understood. Levaraging flow cytometry and multiplex immunofluorescence data, we performed a time-resolved quantitative assessment of immune cell dynamics in tumor-draining lymph node (tdLN) and non-tumor-draining lymph node (non-tdLN) in a melanoma mouse model receiving ACT.
L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy and bevacizumab in newly-diagnosed glioblastoma: expansion of the phase I/II GLORIA trial
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Abstract Rapid vascular recovery is a key feature preceding glioblastoma (GBM) recurrence after radiotherapy (RT). We performed spatial expression analyses, providing a rationale for dual inhibition of two non-redundant, spatially distinct acting factors, CXCL12 and VEGF.
By Frank A. Giordano, Julian P. Layer, Roberta Turiello, Lea L. Friker, Oriol Mirallas, Anna-Laura Potthoff, Thomas Zeyen, Johannes Weller, Elena Sperk, Katharina Sahm, Christoph Oster, Sied Kebir, Niklas Schäfer, Sebastian Kadzik, Mirjam Renovanz, Torsten Pietsch, Sotirios Bisdas, Juan Manuel Sepúlveda-Sánchez, Diego Gómez-Puerto, Maria Vieito, Michael Platten, Eleni Gkika, Oliver M. Grauer, Ghazaleh Tabatabai, Matthias Schneider, Martin Glas Verified, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel, Barbara E. F. Pregler, Peter Hambsch
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Nature
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Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone
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Having established that the TM number influences single-cell migration at the FIZ, we next asked how GB cell migration evolves over consecutive days and whether it differs by anatomical location. We performed repeated 3P microscopy in GB-bearing mice over three to four consecutive days at 24-h intervals (Figure 3A). Large z stacks spanning ∼1 mm covered the entire cortical column and CC (Figure 3B).
By Felix C Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L. Friker, Sonia Leonardelli, Severin Filser, Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A. Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, Martin Fuhrmann
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Cell Press
Verified
IL-17A-producing NKp44(−) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue - Nature Communications
Abstract Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Even among carriers of the same genetic variant, duodenal phenotypes vary, indicating that additional factors, such as the local immune system, play a role. We observe an increase in duodenal IL-17A(+)NKp44(−) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched in adenomas and carcinomas.
Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer - Nature Reviews Urology
Abstract Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours.
T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels
Keywords cancer brain metastasis brain cancer brain metastases tumor immunology immunotherapy intravital imaging lymphocyte recruitment melanoma Introduction Brain metastasis is a frequent complication of melanoma and is associated with a poor prognosis for patients, with a median survival of 4–6 months.1,2 The brain has long been considered an immune-privileged organ.3 However, recently a lymphatic system of the meninges composed of lymphatic vessels located in close proximity along the...
The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer
Keep it Simple: A Proposal for a New Definition of Uncomplicated and Complicated Urinary Tract Infections from the EAU Urological Infections Guidelines Panel
The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer
Get full text access Log in, subscribe or purchase for full access. References Zhao, P. ∙ Li, L. ∙ Jiang, X. ... Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy J Hematol Oncol. 2019; 12:54 Sha, D. ∙ Jin, Z. ∙ Budczies, J. ... Tumor mutational burden as a predictive biomarker in solid tumors Cancer Discov. 2020; 10:1808-1825 3. Marcus, L. ∙ Fashoyin-Aje, L.A. ∙ Donoghue, M. ...
From Tpex to Tex: a journey through CD8+ T cell responses in cancer immunotherapy - Signal Transduction and Targeted Therapy
In a recent study published in Cell, Rahim et al. show that a subset of progenitor exhausted CD8+ T cells (Tpex) in uninvolved, regional lymph nodes (uiLNs) are clonally related to exhausted CD8+ T cells (Tex) in tumors of patients with head and neck squamous cell carcinoma (HNSCC) and following adjuvant immune checkpoint blockade (ICB) these clones expanded in the tumor suggestive of migration from the uiLNs and differentiation into an exhaustion state.1 The work by Rahim et al.
Reply to Jon Griffin. TIME for a Change? Multimarker Assessment of the Tumour Immune Microenvironment and Metastatic Site Biopsy to Improve Immunotherapy Response Prediction in Muscle-invasive Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.
We write in response to the editorial from Griffin [] regarding our manuscript on immunotherapy response prediction using spatial immunephenotypes for distant metastases in metastatic urothelial carcinoma (mUC) []. We thank the author for reporting on our study and welcome the comprehensive and critical discussion of current data for this setting.
Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells
• None Endogenous Glucocorticoid Signaling Regulates Effector Differentiation and Development of Dysfunction in CD8+ T Cells in the Tumor Microenvironment. : • None In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
RAS and PD-L1: A Masters’ Liaison in Cancer Immune Evasion
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewRAS and PD-L1: A Masters’ Liaison in Cancer Immune Evasion © 2017 Elsevier Inc.
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