Michael Leone on Muck Rack

Michael Leone

  • Director of Analytics, Establish The Run
Buffalo
As seen in: MDPI, Stealing Signals, Substack, The Minnesota Star Tribune, Washington Times, St. Louis Post-Dispatch, The Charlotte Observer, Hartford Courant, Arizona Daily Star, The News & Observer and
Director of Analytics @establishtherun. Long suffering #Bills fan.
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Articles

The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia

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By Sylvanus Toikumo, Marc Parisien, Michael Leone, Chaitanya Srinivasan
| The Journal of Clinical Investigation
Abstract Chronic pain is a complex clinical problem comprising multiple conditions that may share a common genetic profile. GWAS have identified many risk loci whose cell-type context remains unclear. Here, we integrated GWAS data on chronic pain with single-cell RNA-Seq (scRNA-Seq) data from human brain and dorsal root ganglia (hDRG) and single-cell chromatin accessibility data from human brain and mouse dorsal horn.
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Opinion: Lamont should not try to import Trump’s dirty energy agenda into CT

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By Michael Leone, Michael lives
| Hartford Courant
Gov. Ned Lamont recently announced that he had met separately with President Trump’s Secretary of Energy and his Secretary of the Interior in February to discuss how to increase the supply of dirty energy in Connecticut. Of course, he didn’t say that this is what he was doing, but instead couched his agenda in the language of affordability.
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Noise Correlations in Balanced Networks with Unreliable Synapses

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By Michael Leone, Chengcheng Huang, Brent Doiron, Carnegie Mellon
| biorxiv.org
Abstract Synaptic physiology is highly stochastic in the neocortex: immediately following an action potential, individual synapses release neurotransmitter unreliably, sometimes even failing to release any vesicles. However, theoretical models of neuronal networks typically neglect this well-established feature of biology, especially recurrent networks.
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