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Articles by Michael Schaefer
Autophagy and intratumoral bacteria abundance influence the prognosis of patients with pancreatic carcinoma
Abstract The biological and clinical significance of the intratumoral microbiota in pancreatic ductal adenocarcinoma (PDAC) remains poorly defined.
Massachusetts Appeals Court Hears Argument on Whether Late-Filed Construction Defect Claims Are Barred by Statute of Repose | JD Supra
Overview On September 16, 2026, the Massachusetts Appeals Court held oral argument in Trustees of the 350 West Broadway Condominium Trust v. Peter Leoutsakos, et al., 2025-P-1506, where the appeals court must decide whether newly added construction defect claims filed against a condominium developer relate back to the date of the initial filing of the lawsuit and may be asserted or are time barred by the six-year limitation in the statute of repose in G. L. c. 260, § 2B. G. L. c.
Effects of prefrontal transcranial direct current stimulation on open-label placebo responses
Abstract Recent research has shown that placebos can have beneficial effects even when given without deception. Such effects have been reported for outcomes including pain, anxiety or emotional distress. However, the mechanisms behind these open-label placebo (OLP) effects still remain unclear. For conventionally concealed placebos, a central role of expectation has been discussed, which has been linked to an engagement of the dorsolateral prefrontal cortex.
NanoBiT screening identifies the azaoxafluorene VT11 as potent tau interaction inhibitor
Abstract Tauopathies are neurodegenerative disorders characterized by accumulating misfolded, insoluble tau protein aggregates in neurons or glial cells. In this study, we screened the Spectrum Collection and other compound libraries for inhibitors of tau self-interaction using a structural complementation reporter system (NanoLuciferase Binary Technology). Resulting candidates were tested in dose-response assays and evaluated for cell toxicity and microtubule destabilization.
Open-label placebos reduce hair cortisol concentrations and psychological distress - a randomized controlled trial
Abstract The exposure to stressful events, such as demanding university exams, is associated with psychological distress and elevated physiological stress responses, which may impair performance. Recent research suggests that open-label placebo (OLP) treatments can effectively reduce psychological distress. However, evidence regarding OLP effects on biomarkers remains limited, highlighting the need for systematic investigation.
Pop Mart Teams With Sony for Paul King’s ‘Labubu’ Movie, Steven Levenson to Co-Write
Pop Mart, a leading company in the designer collectibles and pop culture entertainment industry, is teaming with Sony Pictures Entertainment on its Labubu feature film, to be co-written and directed by “Paddington” filmmaker Paul King.
Neon in Talks to Sell Stake to Department M
Neon is in talks to sell a significant stake to Department M, The Wrap has learned.Department M is being backed by a consortium of private investors in the effort.
Ideal efficacy photoswitching for chromocontrol of TRPC4/5 channel functions in live tissues - Nature Chemical Biology
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Abstract Precisely probing the endogenous roles of target proteins is crucial for biological research. Photochemical tools can be photoactuated with high spatiotemporal resolution but often they are unreliable in vivo because spatiotemporal variations of reagent concentration result in inhomogeneous bioactivity.
By Markus K Muller, Markus P. Müller, Konstantin Niemeyer, Navin K. Ojha, Sebastian Porav, Deivanayagabarathy Vinayagam, Nicole Urban, Fanny Büchau, Katharina Oleinikov, Mazen Makke, Claudia Bauer, Aidan Johnson Verified, Stephen P. Muench, Frank Zufall Verified, Dieter Bruns, Yvonne Schwarz, Stefan Raunser, Trese Leinders-Zufall, Robin S. Bon, Michael Schaefer, Oliver Thorn-Seshold
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Nature
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The Potential of the G20 for Progress on Climate and Sustainability during Geopolitical Turbulence
The international framework for achieving tangible progress in climate protection and sustainable development has significantly deteriorated in recent years. Russia’s war of aggression against Ukraine, along with the repositioning of the current U.S. administration — particularly in its approaches towards China, Russia, and the United Nations — has unsettled the rules-based international order and complicated consensus-building in multilateral negotiations.
Pioneers Post Third Straight Shutout With 2-0 Win
DUBUQUE, Iowa – Two first half goals led the University of Wisconsin-Platteville men’s soccer team (9-1-2) to a 2-0 road win over Dubuque (4-8-2) on Tuesday night from Oyen Field in Dubuque, Iowa. DUBUQUE, Iowa – Two first half goals led the University of Wisconsin-Platteville men's soccer team (9-1-2) to a 2-0 road win over Dubuque (4-8-2) on Tuesday night from Oyen Field in Dubuque, Iowa.
Design and Construction Management Professional Reporter - Summer 2024
Pennsylvania Court Finds the Statute of Repose Applies Even When the Building Code was Not Followed and How Massachusetts Courts Have Similarly Addressed the Issue By: Dillon Aisenberg Louisiana Court Holds Parties to Construction Contract Are on Equal Footing and Owner not Under Duress in Agreeing to Change Order in Order to Complete Project on Time and Begin Revenue Stream By: Matthew Gendreau Tennessee Limits the Application of Economic Loss Doctrine in Construction Cases By: Michael...
A phosphate-binding pocket in cyclin B3 is essential for XErp1/Emi2 degradation in meiosis I
Abstract To ensure the correct euploid state of embryos, it is essential that vertebrate oocytes await fertilization arrested at metaphase of meiosis II. This MII arrest is mediated by XErp1/Emi2, which inhibits the ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome). Cyclin B3 in complex with Cdk1 (cyclin-dependent kinase 1) is essential to prevent an untimely arrest of vertebrate oocytes in meiosis I by targeting XErp1/Emi2 for degradation.
Pioneers Extend Unbeaten Streak To Fourteen With Win
ELSAH, Ill. – The University of Wisconsin-Platteville men’s soccer team (10-0-4) moved its unbeaten streak to 14 games with 3-0 win over Principia (2-9-1) on Saturday afternoon at Principia Soccer Field in Elsah, Illinois. ELSAH, Ill. – The University of Wisconsin-Platteville men's soccer team (10-0-4) moved its unbeaten streak to 14 games with 3-0 win over Principia (2-9-1) on Saturday afternoon at Principia Soccer Field in Elsah, Illinois.
A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis - PubMed
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Europa zwischen China und den USA: Unentschlossen inmitten von Giganten
50 Jahre sind eine lange Zeit im Leben eines Menschen, 50 Jahre in der Geschichte eines Landes dagegen nur ein Wimpernschlag. Aber die Entwicklung der deutsch-chinesischen Beziehungen in den letzten 50 Jahren mutet an wie ein historischer Quantensprung. Lesen Sie weiter mit Tagesspiegel Plus Nie waren verlässliche Informationen wichtiger Stark werbereduziert in der Tagesspiegel App Exklusive Inhalte für Tagesspiegel Plus-Leser Ohne Risiko: Jederzeit kündbar Schon Digital-Abonnent? Hier anmelden
How delivery is blurring the line between retail and foodservice
The digital marketplace is reshaping how restaurants and supermarkets serve their guests. Michael Schaefer | Dec 21, 2021 Recent reports have suggested that Amazon is trialing a service similar to Instacart in the U.K., providing third-party delivery fulfillment to at least two major supermarket chains and same-day delivery for its Amazon Prime customers.
Where the virtual-restaurant trend might be headed
1270068772 / iStock / Getty Images Plus Consumer demand for delivery is not going away. Delivery-only brands took off in the pandemic, but what happens as life gets back to normal? Michael Schaefer | Nov 24, 2021 Virtual restaurants — online-only establishments with no public-facing outlets — have long existed alongside third-party delivery aggregators like UberEats and DoorDash, but the pandemic has radically expanded their reach and changed the dominant business model.
Oxidation of V(IV) by Birnessite: Kinetics and Surface Complexation
Vanadium is a redox-active metal that has been added to the EPA’s Contaminant Candidate List with a notification level of 50 μg L–1 due to mounting evidence that VV exposure can lead to adverse health outcomes. Groundwater V concentration exceeds the notification level in many locations, yet geochemical controls on its mobility are poorly understood. Here, we examined the redox interaction between VIV and birnessite (MnO2), a well-characterized oxidant and a scavenger of many trace metals.
Quantifying Megatrends: Premiumisation
In April 2021, Euromonitor ran a webinar Quantifying Megatrends: Expanding Your Portfolio in the Right Spaces, which discussed Euromonitor’s new tool for quantifying megatrends, and shared the methodology behind the data and the key findings. Premiumisation is a key megatrend identified by Euromonitor International’s network of industry, country, economic and consumer experts as having the furthest-reaching impact on industries and consumers in the future.
Firing Increases Arsenic Leaching from Ceramic Water Filters via Arsenic and Iron Phase Transformations
Ceramic water filters (CWFs) are produced globally using local clay sources and can effectively remove bacterial pathogens during point-of-use water treatment. The ceramic production process involves firing clay mixed with burnout material at temperatures of 800–1100 °C, which induces mineralogical changes leading to increased arsenic (As) leaching from CWF material compared to source clay.
Five Trends Driving the Era of Food on Demand
Technology is not just changing where we eat, but what we eat. As the lines between foodservice and retail, at-home and away from home, continue to blur, more of our food will be prepared for us by others. This trend is leading to what Euromonitor International has dubbed, “The Era of Food on Demand.” Coronavirus (COVID-19) has accelerated the development of this trend.
Five trends driving the era of food on demand
Reading time: 4 mins Technology is not just changing where we eat, but what we eat. As the lines between foodservice and retail, at-home and away from home, continue to blur, more of our food will be prepared for us by others. This trend is leading to what Euromonitor International has dubbed, “The Era of Food on Demand.” Coronavirus (COVID-19) has accelerated the development of this trend.
ゴーストキッチン、バーチャルレストランの進化は次なるステージへ | Market Research Blog
本記事の内容は、Nation’s Restaurant Newsのオンライン版に掲載されたものです。 ※本記事は英語でもご覧頂けます：Ghost Kitchens, Virtual Restaurants Enter Next Stage of Evolution 米国（および世界）の飲食店業界では、この2年ほど、「ゴーストキッチン」や「バーチャルレストラン」というバズワードが流布している。新型コロナウイルス（COVID-19）のパンデミックをきっかけに飲食店業界では新しいビジネスモデルが一気に広がり、全てのステークホルダーにとって経済的にも持続可能である、デリバリーサービスを中心とした未来を構築するための取り組みが進んでいる。...
Ghost Kitchens, Virtual Restaurants Enter Next Stage of Evolution
A version of this article originally appeared in the online issue of Nation’s Restaurant News. Ghost kitchens and virtual restaurants have been the buzzwords in the U.S. (and global) restaurant industry over the last two years. The pandemic has driven an explosion in new business models, as the industry grapples with building a delivery-centric future that is financially sustainable for all stakeholders.
Getting B2B and B2C ecommerce to work in harmony
As a wholesale distributor of chimney products, selling direct to consumers was never on Lindemann Chimney Supply’s radar when it came to ecommerce. B2B sales are its core business and remained so after the company relaunched its ecommerce site in 2016. Building a B2C business was never a strategy; it was simply a byproduct of launching a new site that is easier to navigate and provided a better user experience.
Manganese, Arsenic, and Carbonate Interactions in Model Oxic Groundwater Systems
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVContaminants in Aqua...Contaminants in Aquatic and Terrestrial EnvironmentsNEXT Michael V. Schaefer Michael V.
Daily Legal News
Domestic Relations 382123 Date Filed August 4, 2020 Case Number DM 382123 Judge Plaintiff Filed by. Lee A. Schaefer 3506 Riverside Avenue Plaintiff's Attorney Defendant Michael J. Schaefer 6607 Laverne Avenue Parma OH 44129 About your information and the public record.
Dust Sources in the Salton Sea Basin: A Clear Case of an Anthropogenically Impacted Dust Budget
The Salton Sea Basin in California suffers from poor air quality, and an expanding dry lakebed (playa) presents a new potential dust source. In 2017–18, depositing dust was collected approximately monthly at five sites in the Salton Sea Basin and analyzed for total elemental and soluble anion content. These data were analyzed with Positive Matrix Factorization (PMF).
Late‐stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Communication Late‐stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents Paul Knochel Corresponding Author E-mail address: paul.knochel@cup.uni-muenchen.de Ludwig-Maximilians-Universitat Munchen, Department of Chemistry, Butenandtstr.
Late‐stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Communication Late‐stage Functionalization of Peptides and Cyclopeptides using Organozinc reagents Paul Knochel Corresponding Author E-mail address: paul.knochel@cup.uni-muenchen.de Ludwig-Maximilians-Universitat Munchen, Department of Chemistry, Butenandtstr.
Could Radiofrequency Ablation Provide Relief for Painful Osteoarthritis in Your Knees?
Osteoarthritis commonly affects the knee joint, which explains the hundreds of thousands of knee replacement surgeries performed every year. But surgery is an option only after non-surgical measures have failed. Even then, it isn’t the answer for everyone. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services.
Soar Eagles
Editor: With age comes memory loss, among the loss of other body functions, but I don’t ever remember seeing the (Woodsboro) Eagles at 8-0 this late in the season. If I need correcting, let me know. This team is a testament to the gritty folks of Woodsboro. Soar Eagles. Michael Schaefer, Pasadena
PM&R Fellowships in Sports and Musculoskeletal Medicine: Gateways to Deep Experiential Learning
During his year as a sports medicine fellow with Cleveland Clinic’s Department of Physical Medicine and Rehabilitation (PM&R), Yogen Patel, DO, worked with athletes ranging from high school students to professionals. One of his most memorable experiences came last winter, when he cared for a top college swimmer who had chest pain.
How to Stay Fit During the Cycling Off-Season
The cycling off-season may mean hanging up your bike for months at a time. Or, it may just mean that the elements are keeping you from biking as regularly as you would like. But what are the best ways to stay in shape for the road when the weather has you sidelined? Michael Schaefer, MD, an avid cyclist and Cleveland Clinic’s Director of Musculoskeletal Physical Medicine and Rehabilitation, says you can retain your base strength, but you should also focus on recovery during the off-season.
Cycling Saddle Sores: 5 Simple Prevention Tips
Whether you’re new to cycling or a seasoned pro, you sometimes pay for that time on the seat. Painful red bumps, sometimes referred to as “saddle sores,” can develop on your thighs and groin area. They may seem like a natural part of riding a bike, especially when you travel longer distances. However, there are ways to prevent them. First, it’s important to understand the root causes. It’s easy to assume that friction from your bike’s seat is the problem.
Cycling Gear: 8 Must-Haves When You Ride
Whether you’re an avid cyclist or just taking your bicycle out for a spin once in awhile, it’s important to equip yourself with the right gear. Dressing properly not only improves comfort, but it can make your next ride safer. And, it’s the key to reducing injury risks as well.
Cycling at Night: 4 Must-Read Safety Tips
When it comes to riding a bicycle at night, the best advice is — avoid it. Michael Schaefer, MD, Director of Musculoskeletal Physical Medicine and Rehabilitation at Cleveland Clinic, suggests staying indoors on a stationary trainer or a spin bike if you want to rack up more cycling time after dark. That being said, many avid cyclists find themselves riding at night eventually — either inadvertently or on purpose.
a growth catalyst or cannibalizing opportunity?
Delivery is growing faster than any other dining occasion, but can it create incremental sales for foodservice overall? Cost is still a barrier for greater levels of participation, but with better technology, apps and more digital engagement than ever, food and dining is increasingly available at the push of a button. This could have an impact on delivery’s long-term potential to draw more of the consumer’s meals to foodservice.
Incidental haptic sensations influence judgment of crimes
People are often judging the behaviors of others in a legal capacity, for example as a judge or member of a jury. While we assume that these processes are fair and consider only legal aspects of the relevant situations, we know that in real life there are numerous situations in which so called extralegal factors are relevant. Here we aimed to experimentally investigate the influence of incidentally and briefly explored hard and soft objects on subsequent judgments of the severity of crimes.
4 Injections That Can Banish Joint Pain For Months
If you’re one of the 30 million adults in the United States who suffer with joint pain, you know the pain often is debilitating. It can keep you from staying active and even make daily chores seem impossible. What you might not know is that your doctor can treat you with more than pills or surgery. Depending on the severity of your pain, injections can be another option for easing your joint pain and get you moving again, says physiatrist Michael Schaefer, MD.
Implanted Shoulder Stimulator Provides New Option for Post-Stroke Shoulder Pain
A 64-year-old woman who had a stroke in 2007 presented to Cleveland Clinic’s Department of Physical Medicine and Rehabilitation in spring 2017 complaining of hemiplegic pain and weakness in her left shoulder. She was unable to take anti-inflammatory medications due to stroke risk. She had tried transcutaneous electrical stimulation (TENS) for her shoulder pain and underwent physical therapy and occupational therapy, all without much relief.
How You Can Get Back to Bicycling
Warmer weather can be a great time to rekindle an old love — with the bicycle! When we were children, we rode our bikes all over the neighborhood. These simple machines gave us a delicious feeling of speed and freedom. Now that we’re adults, bicycling offers an excellent form of exercise, especially for those of us who suffer with long-term joint problems. If this all sounds great and you want to get out there and ride, here are a few important considerations.
Humana Research on Medication Adherence and Medicare Advantage Wins Prestigious Awards
Award-winning research showed a lower mortality rate for Medicare Advantage members; demonstrated that medication adherence is associated with more Healthy Days More excellent work involving co-authors from across Humana. Internal collaboration at its best! Congratulations to Tristan Cordier, Lane Slabaugh, Todd Prewitt, Peinie Young, Eric Havens, and Vipin Gopal.
Exodus: Tanrılar ve Krallar
Exodus: Tanrılar ve Krallar Hakkında Sıkça Sorulan Sorular Oyuncuları kim? Christian Bale, Joel Edgerton, Aaron Paul, Sigourney Weaver, Ben Kingsley, John Turturro Seslendirenler kim? Umut Tabak, Canan Sanan, Ercan Demirel, Rıza Karaağaçlı, İskender Bağcılar, Ceyda Saltadal Ne zaman çıktı? 12 Aralık 2014 Exodus: Tanrılar ve Krallar filmi nerede çekildi? Exodus: Tanrılar ve Krallar filmi İspanya, ABD, İngiltere'de çekilmiştir. Kaç saat? 2 saat 30 dakika IMDb puanı kaç?
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