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Articles by Michael Sixt
Dynamic protrusions mediate crawling motility in Asgard archaea
Abstract Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of ‘eukaryotic signature proteins’3,4,5,6.
Substrate heterogeneity promotes cancer cell dissemination through interface roughening
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Although studies of tumor invasion have mainly emphasized the evolution of genetic and epigenetic heterogeneity, cellular behaviors also depend on the physical microenvironment.
Nuclear squeezing wakes up dendritic cells - Nature Immunology
Dendritic cells migrate to and from lymph nodes in response to chemokine gradients.Data now show that steady-state migration of these cells can be triggered by a mechanosensitive pathway.
Principles of disease defence in organisms, superorganisms and societies - Nature Reviews Immunology
Social distancing is an effective way to prevent the spread of disease in societies, whereas infection elimination is a key element of organismal immunity.
Multitier mechanics control stromal adaptations in the swelling lymph node - Nature Immunology
Abstract Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale.
T Cells: Bridge-and-Channel Commute to the White Pulp
In contrast to lymph nodes, the lymphoid regions of the spleen—the white pulp—are located deep within the organ, yielding the trafficking paths of T cells in the white pulp largely invisible. In an intravital microscopy tour de force reported in this issue of Immunity, Chauveau et al. show that T cells perform unidirectional, perivascular migration through the enigmatic marginal zone bridging channels.
Gut Homeostasis: Active Migration of Intestinal Epithelial Cells in Tissue Renewal
• None Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. : • None Tales from the crypt: new insights into intestinal stem cells. : • None Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. : • None Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.
The Neural Crest Pitches In to Remove Apoptotic Debris
Aglaja Kopf Michael Sixt DOI:https://doi.org/10.1016/j.cell.2019.08.047 In this issue of Cell, Zhu et al. show that in the developing zebrafish, neural crest cells can act as professional phagocytes and directionally approach apoptotic cells to clear the larval nervous system from cell debris. To read this article in full you will need to make a payment Purchase one-time access Read-It-Now Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost.
Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
AbstractDendritic cells (DCs) are sentinels of the adaptive immune system that reside in peripheral organs of mammals. Upon pathogen encounter, they undergo maturation and up-regulate the chemokine receptor CCR7 that guides them along gradients of its chemokine ligands CCL19 and 21 to the next draining lymph node. There, DCs present peripherally acquired antigen to naïve T cells, thereby triggering adaptive immunity.This article is protected by copyright. All rights reserved
The Dynamic Cytokine Niche
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewThe Dynamic Cytokine Niche© 2017 Elsevier Inc.
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