Aglaja Kopf

Abstract Arthropods are ancient vectors of infectious disease that alter the immune environment of the skin during feeding. The epidermis and its immune sentinels, including Langerhans cells, are critical for protection against ectoparasitic arthropods such as ticks. Here, we investigate how human Langerhans cells respond to clinical and experimental tick bites and concomitant infection with the tick-borne bacterium Borrelia burgdorferi.

• None Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans. : • None Tales from the crypt: new insights into intestinal stem cells. : • None Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. : • None Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Aglaja Kopf Michael Sixt DOI:https://doi.org/10.1016/j.cell.2019.08.047 In this issue of Cell, Zhu et al. show that in the developing zebrafish, neural crest cells can act as professional phagocytes and directionally approach apoptotic cells to clear the larval nervous system from cell debris. To read this article in full you will need to make a payment Purchase one-time access Read-It-Now Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost.