Micheal Sandhu on Muck Rack

Micheal Sandhu

As seen in: Nature
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Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis

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By Srinivas Aluri, Kimo Bachiashvili, Jong Jin Jeong, Shanisha Gordon-Mitchell, Samarpana Chakraborty, Jung-In Yang, Srabani Sahu, Sanjay Pandey , Mahinder Paul, Wenjun Deng, Rahul Sanawar, Leah Kravets, Sarah Aminov, Ritesh Aggarwal, Beamon Agarwal, Divij Verma, Gaurav Choudhary, Tushar D. Bhagat, Milagros Carbajal, Rongbao Zhao, Kith Pradhan, Shahina Maqbool, Seong-Jin Kim, Ulrich Steidl, Aditi Shastri, Marc H.G.P. Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Anjali Budhathoki, Micheal Sandhu, Plabani Sahu
| Nature
Abstract Erythropoiesis is a tightly regulated process involving rapid cell proliferation with orderly differentiation to ensure production of millions of RBCs. TGF-β1 is a key regulator of erythropoiesis, however, the mechanisms via which it regulates erythropoiesis are not well elucidated. Using myelodysplastic syndromes patient samples, we show that elevated TGF-β1 and SMAD2 signaling correlates with the degree of anemia.
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