Michele Duval on Muck Rack

Michele Duval

As seen in: Journal of Medical Case Reports, The Journal of Biological Chemistry

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Articles

Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1

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By Edward Pokrishevsky, Michèle G. DuVal, Michele Duval, Luke McAlary, Sarah Louadi
| The Journal of Biological Chemistry Verified
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons. Neuronal superoxide dismutase-1 (SOD1) inclusion bodies are characteristic of familial ALS with SOD1 mutations, while a hallmark of sporadic ALS is inclusions containing aggregated wild-type TAR DNA-binding protein 43 (TDP-43).
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