Weight-loss drugs significantly improve health, though they’re also tied to increased spending on other medical care that’s sustained over time, a new study found. ’s semaglutide, the active ingredient in both Wegovy and Ozempic, led to significant reductions in weight, blood pressure and cholesterol after two years. Excluding the price of the drugs, which can top $1,000 a month, health care costs for insurers rose by $67 a month in patients with diabetes and $81 a month for those without it.