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Articles by Michelle Percharde
Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development - Nature Communications
Abstract Mammalian pre-implantation embryos accumulate substantial lipids, which are stored in lipid droplets (LDs). Despite the fundamental roles of lipids in many cellular functions, the significance of building-up LDs for the developing embryo remains unclear.
Author Correction: Maternal vitamin C regulates reprogramming of DNA methylation and germline development
Correction to: Nature https://doi.org/10.1038/s41586-019-1536-1 Published online 04 September 2019 In this Letter, draft versions of the five Supplementary Data files were inadvertently uploaded. These Supplementary Data files have all now been replaced online. Author information Author notes Stephanie P.
Maternal vitamin C regulates reprogramming of DNA methylation and germline development
Abstract Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals1,2. The embryonic germline is of particular interest because of the potential for intergenerational epigenetic effects.
A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity
Transposable elements represent nearly half of mammalian genomes and are generally described as parasites, or “junk DNA.” The LINE1 retrotransposon is the most abundant class and is thought to be deleterious for cells, yet it is paradoxically highly expressed during early development. Here, we report that LINE1 plays essential roles in mouse embryonic stem cells (ESCs) and pre-implantation embryos.
Global Hypertranscription in the Mouse Embryonic Germline
Global Analysis of Hypertranscription by CNN RNA-Seq in E13.5 PGCs The EU data show that nascent transcription is globally elevated in PGCs but do not resolve which genes are transcriptionally amplified. Are most/all transcripts globally elevated in the developing germline, or do PGCs only express a subset of genes at very high levels? To answer this question, we performed CNN RNA sequencing (RNA-seq) at E13.5 (Tables S1x Download (5.49 MB ) Table S1.
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