Miguel Blanquer

Multiple myeloma (MM) is a clonal neoplastic proliferation of plasma cells that accounts for 1% of all cancers and 10–15% of hematological malignancies. Cytogenetic aberrations, detected by fluorescent in situ hybridization (FISH), directly impact prognosis and stratify patients into standard-risk and high-risk cytogenetics groups. 85% of newly diagnosed MM patients (NDMM) have standard-risk cytogenetics according to Revised International Staging System (R-ISS).

New Results doi: https://doi.org/10.1101/2023.07.27.550790 Abstract Despite a considerable interest in understanding the mechanisms regulating nucleus structure, chromatin organization and nuclear positioning over decades, the exact significance of the variety of morphologies and positioning that cell nuclei can adopt and their relationship in cellular function is still far from being clearly understood.