Miguel Reyes on Muck Rack

Miguel Reyes

As seen in: El Topo, Color Research & Application, Nature, MDPI, Science Magazine, Cell Press, Mining Engineering
Mirón y preguntón / Host del @podcasteltopo & productor de @lanoficcion. 🌱🌎🎥🎙🏔🌔
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Articles

Scoring gene importance by interpreting single-cell foundation models

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By Maxwell P. Gold, Miguel Reyes, Nathaniel Diamant, Tony Chien-Yen Kuo, Ehsan Hajiramezanali, Jane W. Newburger, Mary Beth F. Son, Pui Lee, Gabriele Scalia, Aicha BenTaieb, Sharookh B. Kapadia, Anupriya Tripathi, Héctor Corrada Bravo, Graham Heimberg, Tommaso Biancalani
| Nature Verified
Abstract Determining a gene’s functional importance within a cellular context has long been a challenge, as absolute expression level is an unreliable indicator. Here we introduce SIGnature, a framework for scoring gene importance using attributions derived from single-cell RNA-sequencing (scRNA-seq) foundation models. Attribution scores reduce technical noise, emphasize regulatory genes and facilitate cross-dataset comparison—a core challenge for scRNA-seq analyses.
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Rapid and repeated evolution of myosin copy number in threespine stickleback

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By Alyssa M. Yoxsimer, Rhea Daugherty, Emily Hare, Yingguang Frank Chan, Felicity Jones, Garrett A. Roberts Kingman, Emma G. Offenberg, Timothy R. Howes, Haili Zhang, Alex A. Pollen, Shannon Brady, Kathleen T. Xie, Heidi Chen, Craig B. Lowe, Eric Au, Jane Grimwood, Jeremy Schmutz, Richard Myers, Dolph Schluter, David Heins, Miguel Reyes, John Baker, Bjarni Jónsson, Thomas E. Reimchen, Michael Bell, David M. Kingsley
| Cell Press Verified
Keywords copy-number variation adaptive evolution myosin heavy chain species pairs contemporary evolution stickleback Gasterosteus aculeatus microhomology-mediated break-induced replication non-allelic homologous recombination Introduction Copy-number variations (CNVs) are the most abundant type of variation in vertebrate genomes by total base pairs affected1 and make up approximately 12% of the human genome.2 CNVs can change the structure of genes at breakpoints or alter the levels of...
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Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

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By Miguel Reyes, Michael Filbin, Roby P. Bhattacharyya, Abraham Sonny
| Science Magazine Verified
Myeloid suppressive cells enter the arena Patients with bacterial sepsis or severe COVID-19 have increased numbers of suppressive myeloid cells in their blood. Reyes et al. now show that similar cells can be induced by treatment of healthy human bone marrow progenitor cells in culture with plasma from patients with bacterial sepsis or severe COVID-19.
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