Mihyun Bae on Muck Rack

Mihyun Bae

As seen in: Nature
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Articles

Glycine-modulating Slc6a20a -ASO restores NMDA receptor function in SHANK2 and SHANK3 -mutant mice and cortical organoids

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By Junyeop Daniel Roh, Yeji Yang, Suho Lee, Esther Yang, Hyeonji Kim, Hyun Chang Kim, Jin Kim, Eunjoon Kim, Mihyun Bae, Yusang Oh, Woo-Chang Hwang, Hyunjee Jang, Hyung-Wook Choi
| Nature
Abstract Suppressed NMDA receptor (NMDAR) function contributes to multiple brain disorders, including schizophrenia, autism spectrum disorder (ASD), and NMDAR encephalitis. Previous attempts to restore NMDAR activity by increasing ambient glycine, a critical co-agonist, through GlyT1 inhibition have yielded mixed outcomes, partly due to GlyT1’s extensive expression in essential brainstem regions.
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