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Keywords neuroinflammation ALS RIPK1 microglia astrocytes single-nucleus RNA-seq Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease leading to progressive motor neuron loss and muscle weakness.
Abstract Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising approaches for HIV cure. Here, we develop and evaluate a trispecific antibody (Ab), N6/αCD3-αCD28, that targets three independent proteins: (1) the HIV envelope via the broadly reactive CD4-binding site Ab, N6; (2) the T cell antigen CD3; and (3) the co-stimulatory molecule CD28.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
