Dimitry Ofengeim on Muck Rack

Dimitry Ofengeim

Norwood
As seen in: Nature, Cell Press
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Articles

A transcriptomic microglia taxonomy across mouse and human pathologies

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By Chintan Chhatbar, Roman Sankowski, Michael Schulz, Takashi Shimizu, Marius Schwabenland, Ori Staszewski, Christian Scheiwe, Katharina Borst, Anaelle Aurelie Dumas, Wesley Brandao, Omar Mossad, Adrià Dalmau Gasull, Maximilian Frosch, Daniel Erny, Martin Diebold, Janaki Manoja Vinnakota, Koliane Ouk, Inken Waltl, Michael LaMorte, Timothy R. Hammond, Giovanni Di Liberto, Ilena Vincenti, Mario Kreutzfeldt, Ibrahim T Mughrabi, Yousef Al-Abed, Thomas Blank, Melanie Meyer-Luehmann, Yanick J. Crow, Dimitry Ofengeim, Robert Zeiser, Jutta Gärtner, Andreas Meisel, Martin Schwemmle, Ulrich Kalinke, Jürgen Beck, Bertram R Bengsch, Robert Thimme, Oleg Butovsky, Tamara Seredenina, Richard M. Ransohoff, Francisco J. Quintana, Katrin Kierdorf, Doron Merkler, Christine Stadelmann, Josef Priller, Marco Prinz, Stefan Nessler, Ella Trost, Daniel Berchtold, Elena Guffart, Katharina Ternka, Mihaela Guranda, Marina Friesen, Nellwyn Hagen, Matthias Kettwig
| Nature Verified
Abstract Single-cell studies have revealed substantial microglial diversity in development, homeostasis and disease. However, a framework enabling comparison and stratification of microglial states across contexts is needed. Here we generated an atlas of myeloid cell states by single-cell RNA sequencing more than one million central nervous system cells from more than 30 physiological and pathological conditions.
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Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis

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By Matija Zelic, Anna S. Blazier, Fabrizio Pontarelli, Michael LaMorte, Jeremy Calvin Huang, Ozge E. Tasdemir-Yilmaz, Yi Ren, Sean Ryan, Cynthia Shapiro, Caroline Morel, Pavithra Krishnaswami, Mikhail Levit, Disha Sood, Yao Chen, Joseph Gans, Xinyan Tang, Fen Huang, Bailin Zhang, James Berry, Dinesh Bangari, Giorgio Gaglia, Dimitry Ofengeim, Timothy Hammond, Jennifer Hsiao-Nakamoto
| Cell Press Verified
Keywords neuroinflammation ALS RIPK1 microglia astrocytes single-nucleus RNA-seq Introduction Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease leading to progressive motor neuron loss and muscle weakness.
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Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro - Communications Biology

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By Dimitry Ofengeim, Agnes Cheong, Thomas A. Natoli
| Nature Verified
Abstract While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism in driving organ dysfunction. Here, we used a small molecule inhibitor of glucosylceramide synthase to modulate GSL levels in three mouse models of distinct renal pathologies: Alport syndrome (Col4a3 KO), polycystic kidney disease (Nek8jck), and steroid-resistant nephrotic syndrome (Nphs2 cKO).
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