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Milene Volpato on Muck Rack

Milene Volpato

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Articles

Apoptotic modulators enhance oncolytic virus-induced cytokine killing in acute myeloid leukaemia (AML)

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By Samuel Raymond Heaton, Tyler J Barr, Richard Baugh, Stewart McConnell, Victoria Jennings, Christy Ralph, Manish Jain, Richard Kelly, Christopher Parrish, Basem Askar, Noura Alzamel, Milene Volpato, Fiona Errington-Mais
| Nature Verified
Abstract Approximately 3000 adult patients are diagnosed with AML in the UK each year. Current intensive treatments are not well-tolerated by elderly patients, and the 5-year survival rate is only 5–15%, highlighting the need for novel and effective therapies. Oncolytic viruses (OVs) preferentially replicate in cancer cells, resulting in direct oncolysis and induction of innate and adaptive anti-tumour immunity. Unfortunately, the efficacy of OVs remains relatively unexplored in AML.
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