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Articles

Modulating AP-1 enables CAR T cells to establish an intratumoral stemlike reservoir and overcomes resistance to PD-1 blockade

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By Andrew Snyder, Jamie Blum, Ailis Grieshaber, Sarah Garrison, Mitchell G. Kluesner, Carolyn Shasha, Tam Ho, Miles Linde, Feinan Wu, Lauren Meyer, Amelia R Wilhelm, Emma Bingham, Haleema Sadia Malik, Sam Mak, William Sam Nutt, Sydney A. Marsh, Sergio Ortiz-Espinosa, Victor Zepeda
| Science Magazine Verified
Editor’s summary Mechanisms underlying therapeutic resistance to combined chimeric antigen receptor (CAR) T cell and immune checkpoint inhibitor (ICI) therapy are poorly understood. Snyder et al. reveal that CAR T cells failed to sustain a stemlike T cell reservoir in vivo that is required for durable responses to programmed cell death protein 1 (PD-1)–axis blockade.
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Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies

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By Erica T. Goddard, Miles Linde, Shivani Srivastava, Grant Klug
| Cell Press Verified
Pan H. Gray R. Braybrooke J. Davies C. Taylor C. McGale P. Peto R. Pritchard K.I. Bergh J. Dowsett M. et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. N. Engl. J. Med. 2017; 377: 1836-1846 Karrison T.G. Ferguson D.J. Meier P. Dormancy of mammary carcinoma after mastectomy. J. Natl. Cancer Inst. 1999; 91: 80-85 Pedersen R.N. Esen B.Ö. Mellemkjær L. Christiansen P. Ejlertsen B. Lash T.L. Nørgaard M. Cronin-Fenton D.
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