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Articles by Min Wen
Spatial multi-omics identifies regional immunometabolic remodeling and macrophage PCK2-associated T-cell activation in lupus nephritis
Abstract Poor response of lupus nephritis (LN) to conventional therapies frequently results in persistent renal inflammation and progression of chronic renal insufficiency. The complex pathogenesis of LN, characterized by microregional immune heterogeneity and interregional crosstalk, greatly hinders identification of the core immune network initiating disease and development of effective therapeutic strategies.
Home-based modified constraint-induced movement therapy improves distal motor outcomes after botulinum toxin A injection in chronic stroke
Abstract Background: Botulinum toxin type A (BoNT-A) effectively reduces focal spasticity. However, this pharmacological effect often fails to translate into consistent functional gains when patients receive conventional rehabilitation after injection. Methods: Clinical data from 102 patients with chronic stroke and finger flexor spasticity who received ultrasound-guided BoNT-A injections were retrospectively analyzed in a single-center cohort study.
Precision nutrition in companion animals: a response-based framework linking dietary strategies, metabolic function, and measurable clinical outcomes
Abstract Population-level nutrient recommendations provide the foundation for complete and balanced diets in dogs and cats, but they do not fully account for inter-individual variation in nutritional requirements, metabolic phenotypes, and dietary responses. Precision nutrition provides a response-guided framework that integrates individual characteristics with monitored dietary responses to refine nutritional management through repeated reassessment.
Knowledge, attitudes, and practices among guardians toward inherited retinal diseases: a structural equation modeling analysis
Abstract This study aimed to investigate the knowledge, attitudes, and practices (KAP) among guardians toward inherited retinal diseases (IRDs) in children. This multicenter cross-sectional study, conducted from June 23, 2024, to February 23, 2025, invited guardians of children diagnosed with IRDs at the outpatient or inpatient departments of Tongren City People’s Hospital and its affiliated hospitals to complete a questionnaire. Path analysis was employed to examine the relationships among KAP.
Robust neurogenesis in chronic stroke monkeys following mesenchymal stem cell transplantation plus intermittent theta-burst stimulation
Abstract A significant population of chronic stroke patients urgently requires more effective therapies because of functional plateaus and limited intervention options. Intermittent theta-burst stimulation (iTBS) has been increasingly adopted in chronic-phase ischemic stroke management. However, the efficacy decreases over time. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic strategy for chronic stroke management through multiple mechanisms.
CD8 + T cell loss induces autoinflammation in inborn errors of cell death
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Abstract Systemic autoinflammatory diseases (SAID) with inborn errors of cell death (IECD) are caused by overactivation of programmed cell death (PCD). However, the pathogenesis by which PCD leads to autoinflammation remains unclear. Here, we identified IECD patients carrying compound heterozygous RIPK1 variants K377E/R390G with autoinflammatory manifestations. Mechanistically, K377E and R390G mutations suppress NF-κB signaling and activate RIPK1 to promote cell death.
By Jialin Dai, Taijie Jin, Gaixiu Su, Xu Han, Jun Wang, Chenlu Liu, Wenjie Zheng, Qiuye Zhang, Ranran Zhang, Hye Sun Kuehn, Jun Yang, Li Guo, Dan Zhang, Ming Li, Yingjie Xu, Tong Yue, Min Wen, Jia Zhu, Min Sun Kang, Jianming Lai, Feifei Wu, Shihao Wang, Jiahui Zhang, Ivona Aksentijevich, Sergio Rosenzweig, Pui Lee, Junying Yuan, Xiaomin Yu, Qing Zhou
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Nature
Verified
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