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Min-Yue Yin

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Articles

Matrix stiffness promotes colorectal cancer progression via Golgi-dependent cholesterol synthesis

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By Xue Li Verified, Jun-Qi Zhang, Chang-hao Zhang, Yu-Hang Liu, Si-An Xie, Min-Yue Yin, Bo-Shen Lin, Shu-Tian Zhang
| Nature Verified
Abstract Extracellular matrix (ECM) stiffening and metabolic reprogramming are hallmarks of colorectal cancer (CRC) progression; however, the mechanistic link between biomechanical cues and cholesterol metabolism remains poorly defined. Here, we delineate a mechano-metabolic pathway in which matrix stiffness activates the mechanosensitive Ca²⁺ channel Piezo1 to drive structural reorganization of the Golgi apparatus, promoting its close apposition with the endoplasmic reticulum (ER).
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