Minfeng Ying

Abstract Lactate dehydrogenase (LDH) stands at the intersection of pyruvate metabolism. While it is believed that inhibition of LDH redirects pyruvate to mitochondrial metabolism, suppressing glycolysis and boosting oxidative phosphorylation, the mechanism remains largely unexplored. We found that individual LDH A or B knockouts had minimal impact on glycolysis, tricarboxylic acid cycle (TCAC), or oxidative phosphorylation (OXPHOS).

Minfeng Ying, Cheng Guo and Xun Hu1 From the Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China ↵1 To whom correspondence should be addressed: Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang...

Minfeng Ying1, Cheng Guo2 and Xun Hu1* 1Cancer Institute, Zhejiang University, China 2Cancer Institute, the Second Affiliated Hospital, Zhejiang University School of Medicine ↵* Corresponding author; email: huxun{at}zju.edu.cn Author contributions: M.Y. and X.H. conceptualization; M.Y. formal analysis; M.Y. validation; M.Y. and C.G. methodology; M.Y. and X.H. writing-original draft; M.Y. and X.H. writing-review and editing; C.G. software; X.H. supervision; X.H. funding acquisition; X.H....