Skip To Main Content
Mingcui Gong on Muck Rack

Mingcui Gong

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Mingcui

Contact Mingcui, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Identification of scavenger receptor BI as a scavenger of free heme that is essential for protection against hemolysis

|
By Misa Ito, Jianyao Xue, Ling Guo, Dan Hao, Qian Wang, Alexander Williams, Chang-Guo Zhan, Ailing Ji, Preetha Shridas, Wen Su, Shu Liu, Zhenheng Guo, Mingcui Gong, Scott Gordon, Bin Huang, Jianhang Jia, Chieko Mineo, Philip W. Shaul, Xiang-An Li
| Nature Verified
Abstract Severe hemolysis is a life-threatening condition with limited therapeutic options. Although haptoglobin and hemopexin sequester hemoglobin and heme, these protective systems are rapidly saturated during acute hemolysis, leading to the accumulation of cytotoxic free heme. In this study, we identify scavenger receptor BI (SR-BI) as a critical mediator of free heme clearance. SR-BI binds heme and facilitates its hepatic uptake under pathological conditions.
Open in Who Shared View Duplicates (2) Issue with article?
See all 2 articles