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Xiang-An Li

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Articles

Identification of scavenger receptor BI as a scavenger of free heme that is essential for protection against hemolysis

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By Misa Ito, Jianyao Xue, Ling Guo, Dan Hao, Qian Wang, Alexander Williams, Chang-Guo Zhan, Ailing Ji, Preetha Shridas, Wen Su, Shu Liu, Zhenheng Guo, Mingcui Gong, Scott Gordon, Bin Huang, Jianhang Jia, Chieko Mineo, Philip W. Shaul, Xiang-An Li
| Nature Verified
Abstract Severe hemolysis is a life-threatening condition with limited therapeutic options. Although haptoglobin and hemopexin sequester hemoglobin and heme, these protective systems are rapidly saturated during acute hemolysis, leading to the accumulation of cytotoxic free heme. In this study, we identify scavenger receptor BI (SR-BI) as a critical mediator of free heme clearance. SR-BI binds heme and facilitates its hepatic uptake under pathological conditions.
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The Role of Scavenger Receptor BI in Sepsis

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By Xiang-An Li
| MDPI
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