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Articles by Mingkuan Chen
Chemoenzymatic Tagging of Tn/TF/STF Antigens in Living Systems
Aberrant expression of truncated mucin-type O-glycans is a hallmark of cancer.1 These truncated O-glycans, including Tn (GalNAcα-O-Ser/Thr), Thomsen-Friedenreich (Galβ1-3GalNAcα-O-Ser/Thr, TF) and STF (Neu5Acα2-3Galβ1-3GalNAcα-O-Ser/Thr, STF) antigens, are found in many carcinomas such as gastric, colon, breast, lung, esophageal, prostate, endometrial, bladder and pancreatic cancers.1c-2 Upregulation of these antigens correlates with adverse outcomes and decreased patient survival, attracting...
Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation
Highlights • Fucosyl-biotinylation enables the detection of endogenous tumor antigen-specific T cells • Dysfunctional tumor antigen-specific CD8+ T cells upregulate steroid biosynthesis genes • Tumor antigen-suppressive and reactive CD4+ T cells co-exist in tumor microenvironments • Intratumoral bystander T cells are separated into two groups based on PD-1 expression Summary Re-activation and clonal expansion of tumor-specific antigen (TSA)-reactive T cells are critical to the success of...
Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation
Abelin J.G. Keskin D.B. Sarkizova S. Hartigan C.R. Zhang W. Sidney J. Stevens J. Lane W. Zhang G.L. Eisenhaure T.M. et al. Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction. Immunity. 2017; 46: 315-326 Ahmadzadeh M. Pasetto A. Jia L. Deniger D.C. Stevanović S. Robbins P.F. Rosenberg S.A. Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity. Sci. Immunol.
A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates
Molecules presented on the cell surface determine how cells interact with their partners and their environment. Methods for engineering the cell-surface landscape are instrumental for the study of cell–cell communications and the downstream signaling.
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