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Abstract The about 4000-residue L proteins from the Nairoviridae are the largest known viral polymerases, lacking global structural information and promising nucleotide analog (NA) inhibitors. Here we report structures of full-length Nairoviridae Crimean-Congo hemorrhagic fever virus (CCHFV) L including a 3.0-Å-resolution polymerase elongation complex that elucidates mechanisms of both early and late elongation stages.
Abstract Mutations in SHANK3 are a leading monogenic cause of autism spectrum disorder (ASD), often associated with profound sensory abnormalities. However, the impact of SHANK3 deficiency on olfactory processing and the underlying neural mechanisms remains unclear. Here, we identify a cross-species disruption of olfactory valence perception in individuals with SHANK3 mutations and in Shank3 mutant mice.
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