Jiqin Wu on Muck Rack

Jiqin Wu

As seen in: PLOS, Science Magazine, Cell Press, Cell Reports
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Articles

An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element

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By Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong
| Science Magazine Verified
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LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities

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By a. Guangzhou Women, Jiqin Wu, Zhongyuan Tan, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Tan Z, Wu J, Huang L, Wang T, Zheng Z, Zhang J, et al. (2023) LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities. PLoS Pathog 19(9): e1011620.
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Remdesivir overcomes the S861 roadblock in SARS-CoV-2 polymerase elongation complex

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By Jiqin Wu, Haofeng Wang, Qiaojie Liu
| Cell Reports Verified
Highlights • SARS-CoV-2 RdRP elongation complex assembled via multiple nucleotide addition cycles • Remdesivir overcomes the S861 roadblock in SARS-CoV-2 RdRP elongation complex • Remdesivir induces delayed intervention at the equivalent site in EV71 RdRP • Delayed intervention of RdRP by 1'-modified nucleotide analogs may generally occur SUMMARY Remdesivir (RDV), a nucleotide analog with broad-spectrum features, has exhibited effectiveness in COVID-19 treatment.
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