Mirella Pastore

This version is not peer-reviewed. Erwin Gäbele,Isabella Gigante,Mirella Pastore,Antonio Cigliano,Grazia Galleri,Thea Bauer,Elena Pizzuto,Serena Mancarella,Martina Müller,Fabio Marra,Heiko Siegmund,Gianluigi Giannelli,Matthias Evert,Chiara Raggi,Diego F. Calvisi,Sara M. Steinmann  * Erwin Gäbele,Isabella Gigante,Mirella Pastore,Antonio Cigliano,Grazia Galleri,Thea Bauer,Elena Pizzuto,Serena Mancarella,Martina Müller,Fabio Marra,Heiko Siegmund,Gianluigi Giannelli,Matthias Evert,Chiara Raggi,Diego F.

Highlights • MerTK, a member of the TAM family of proteins, is highly expressed in MerTK+/CD206+/CD163+/CD209- macrophages. • In these macrophages, activation of MerTK induces phosphorylation of Akt, STAT3, ERK1/2, p38 and increased expression of VEGF-A. • MerTK activation in macrophages modulates the secretome to promote the profibrogenic phenotype of human HSCs. • Profibrogenic effects of macrophages expressing high levels of MerTK were blocked by knockdown or inhibition of MerTK.