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Miriama Kruta on Muck Rack

Miriama Kruta

As seen in: Nature, Cell Stem Cell
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Articles

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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By Miriama Kruta, Mary Sunshine
| Cell Stem Cell Verified
Highlights • Ex-vivo-cultured HSCs rapidly and massively increase protein synthesis • Hsf1 is activated in culture to promote ex vivo HSC maintenance and proteostasis • Small-molecule activators of Hsf1 enhance HSC maintenance and fitness in culture • Hsf1 is activated in aging HSCs in vivo to promote proteostasis and fitness Summary Maintaining proteostasis is key to resisting stress and promoting healthy aging.
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Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

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By Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta
| Nature Verified
a) Dots plots and histograms showing gating strategy and TMRE intensity for each of the indicated populations in young and old bone marrow in response to BIM 3 μM and 8 μM. CLP: common lymphoid progenitors, MP: myeloid progenitors, LSK: lineage-Sca1+c-kit+, GMP: granulocyte monocyte progenitor, CMP: common myeloid progenitor, MEP: megakaryocyte erythroid progenitor, MPP1: multi-potent progenitor 1, MPP2: multi-potent progenitor 2, HSC: haematopoietic stem cells.
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