Misago D Seth on Muck Rack

Misago D Seth

As seen in: Nature, Frontiers, medRxiv
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Articles

Development of an Oxford nanopore sequencing technology-based whole genome sequencing method for Plasmodium falciparum to support malaria molecular surveillance

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By Catherine Bakari, Aurel Holzschuh, Misago D Seth, Rashid A. Madebe, Dativa Pereus, Celine I. Mandara, Pierre Schneeberger, Jonathan J. Juliano, Jeffrey Bailey, Deus Ishengoma, Christian Nsanzabana
| Nature Verified
Abstract Whole genome sequencing (WGS) is critical for malaria molecular surveillance (MMS). While short-read platforms have been widely used for Plasmodium falciparum genomics; they have limitations in resolving repetitive regions and structural variation in this highly complex genome. Long-read technologies, such as those developed by Oxford nanopore technologies (ONT), offer complementary capabilities and may be particularly suitable for low-resource settings.
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Genetic metrics decode Plasmodium falciparum diversity: complexity of infection, parasite connectivity, and transmission intensity in Mainland Tanzania’s diverse regions

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By Abebe A. Fola, Catherine Bakari, Misago D Seth, BEATUS M Lyimo, Celine I. Mandara, Rashid A. Madebe, Doris D. Mbata, Zachary R Popkin-Hall, Daniel Mbwambo, Sijenunu Aaron, David Giesbrecht, Jonathan J. Juliano, Jeffrey Bailey, Deus Ishengoma, Dativa Pereus, Rebecca DeFeo, Ramadhan Moshi, Ruth B. Mbwambo, Abdallah Lusasi, Samwel Lazaro, Benard Kulohoma, Gerald Juma, Victor A. Mobegi
| Frontiers
Abstract Introduction: Recent evidence indicates that an increasing number of endemic countries have deployed and are using genomic surveillance to determine and monitor the trends and patterns of malaria transmission. This study aimed to evaluate and identify the most informative genetic metrics for establishing and monitoring the genetic diversity of Plasmodium falciparum and its correlation with malaria transmission intensities in Mainland Tanzania.
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Prevalence of subpatent Plasmodium falciparum infections in regions with varying transmission intensities and implications for malaria elimination in Mainland Tanzania

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By Misago D Seth, Zachary R Popkin-Hall, Rule Budodo, Rashid A. Madebe
| medRxiv
The authors have declared no competing interest. This study was fully funded by the Bill & Melinda Gates Foundation [grant number 002202] I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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