1 INTRODUCTION Traumatic injury is one of the leading causes of death worldwide, responsible for nearly five million deaths per year and billions of dollars in hospital costs for trauma-related inpatient care.1, 2 A third of these mortalities are attributed to uncontrolled hemorrhage and trauma-induced coagulopathy (TIC).3 TIC, a multi-phenotypic, dynamic pathology characterized by inhibited thrombin formation, decreased fibrinogen activity, platelet dysfunction, and fibrinolysis...