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Mohammadmersad Ghorbani

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Articles

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

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By Bystrykh L.V, Yanling Hu, Gemma L. Fryatt, Mohammadmersad Ghorbani
| Cell Reports Verified
Highlights • In Alzheimer’s-like pathology, a fraction of microglia undergo replicative senescence • Disease-associated microglia (DAM) display several features of senescence • Prevention of proliferation impairs the development of microglial senescence and DAMs • Prevention of microglial senescence leads to reduced amyloidosis and synaptic damage Summary The sustained proliferation of microglia is a key hallmark of Alzheimer’s disease (AD), accelerating its progression.
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