Mohsen Barzegar

6-OHDA 6-Hydroxydopamine hydrochloride α-syn α-synuclein ROS reactive oxygen species PD Parkinson`s disease PGH pistachio green hull BW body weight PGHE pistachio green hull extract IPTG isopropyl-β-D-thiogalactoside SNpc substantia nigra pars compacta LD50 lethal dose ThT thioflavin T MFB medial forebrain bundle 1 Introduction Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer's and affects approximately 1% of the adult population over 60 years of...

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1 INTRODUCTION Glycation is a nonenzymatic reaction in which free amino groups in proteins react with free carbonyl groups of reducing sugars to form a Schiff's base. This is then converted into a more stable product called the Amadori product. Subsequently, advanced glycation end products (AGEs) are generated through a series of oxidation, dehydration, condensation, cross-linking, and cyclization (González et al., 2020).