Motonari Uesugi on Muck Rack

Motonari Uesugi

As seen in: Nature, ACS Publications, Royal Society of Chemistry
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Articles

Small Molecule Activators of Antitumor Immunity Click to copy article link Article link copied!

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By Vaibhav Singh Verified, Motonari Uesugi
| ACS Publications
Cite Jump to ExpandCollapse ArticleJune 24, 2026 Small Molecule Activators of Antitumor Immunity Click to copy article linkArticle link copied! Vaibhav Pal Singh Vaibhav Pal Singh Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan Motonari Uesugi* Motonari Uesugi Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto...
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High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

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By Thitinee Vanichapol, Misao Takemoto, Motonari Uesugi, Ruby Wangford
| biorxiv.org
Abstract Autosomal dominant polycystic kidney disease (ADPKD) causes the slow, progressive formation of fluid-filled cysts within the kidney that ultimately leads to renal failure. Despite being the most common genetic kidney disease, the range of therapies for ADPKD is limited. Ureteric bud (UB) organoids derived from human pluripotent stem cells (hPSCs) have been used to model ADPKD.
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Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity - Communications Chemistry

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By Masahito Ohue, Nobuaki Matsumori, Motonari Uesugi, Hideaki Kakeya, Kairi Furui
| Nature Verified
Abstract The structural diversity of chemical libraries, which are systematic collections of compounds that have potential to bind to biomolecules, can be represented by chemical latent space. A chemical latent space is a projection of a compound structure into a mathematical space based on several molecular features, and it can express structural diversity within a compound library in order to explore a broader chemical space and generate novel compound structures for drug candidates.
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