Thitinee Vanichapol on Muck Rack

Thitinee Vanichapol

As seen in: The Journal of Clinical Investigation
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Articles

High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

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By Thitinee Vanichapol, Misao Takemoto, Motonari Uesugi, Ruby Wangford
| biorxiv.org
Abstract Autosomal dominant polycystic kidney disease (ADPKD) causes the slow, progressive formation of fluid-filled cysts within the kidney that ultimately leads to renal failure. Despite being the most common genetic kidney disease, the range of therapies for ADPKD is limited. Ureteric bud (UB) organoids derived from human pluripotent stem cells (hPSCs) have been used to model ADPKD.
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Permanent defects in renal medullary structure and function after reversal of urinary obstruction

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By JCI Insight, Thitinee Vanichapol, Alex Gonzalez, Rachel Delgado
| The Journal of Clinical Investigation
ResearchNephrology Open Access | 10.1172/jci.insight.187008 JCI Insight. https://doi.org/10.1172/jci.insight.187008. Copyright © 2025, Vanichapol et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine, and increasing the risk of progressive kidney disease.
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Partial repair causes permanent defects in papillary structure and function after reversal of urinary obstruction

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By Alex Gonzalez, Rachel Delgado, Maya Brewer, Thitinee Vanichapol
| biorxiv.org
Abstract Urinary obstruction causes injury to the renal papilla and leads to defects in the ability to concentrate urine which predisposes to progressive kidney injury. However, the regenerative capacity of the papilla after reversal of obstruction is poorly understood.
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