Mridu Middha

We performed a genome-wide scan for genetic variants associated with PCa-specific mortality and identified several SNPs associated with unfavorable prognosis. Notably, by adjusting for known predictors of PCa outcome, the SNPs we identified have direct effects on survival time after initial cancer diagnosis rather than risk of developing disease, or stage or grade at diagnosis.Twelve SNPs at seven independent loci were associated with PCa-specific survival time (p < 1 × 10−6).