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MTA-ELTE Statistical

As seen in: Science Magazine, BioRxiv, Cell Press, Physical Review B
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Articles

How mutation accumulation depends on the structure of the cell lineage tree

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By Imre Derényi, MTA-ELTE Statistical, Marton Demeter, ELTE Eötvös
| Physical Review B
All the cells of a multicellular organism are the product of cell divisions that trace out a single binary tree, the so-called cell lineage tree. Because cell divisions are accompanied by replication errors, the shape of the cell lineage tree is a key determinant of how somatic evolution, which can potentially lead to cancer, proceeds. Carcinogenesis requires the accumulation of a certain number of driver mutations.
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Distinguishing excess mutations and increased cell death based on variant allele frequencies

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By Gergely Tibély, MTA-ELTE Statistical, Dominik Schrempf, Imre Derényi
| BioRxiv
New Results Gergely Tibély, View ORCID ProfileDominik Schrempf, View ORCID ProfileImre Derényi, View ORCID ProfileGergely J. Szöllősi doi: https://doi.org/10.1101/2021.02.12.430830 Abstract Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mutation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two.
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Synergistic Benefits of Group Search in Rats

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By Máté Nagy, MTA-ELTE Statistical, Hungarian Academy, Eötvös Loránd
| Cell Press Verified
Highlights • Search strategies of rats in a maze revealed by using automated video tracking • A decision-making hierarchy allows rats to surpass random search behavior • Social interactions improve the efficiency in finding the target • Agent-based simulations confirm emergent collective benefits of simple decision rules Summary , 2 Bartumeus F. Peters F. Pueyo S. Marrasé C. Catalan J. Helical Lévy walks: adjusting searching statistics to resource availability in microzooplankton. Proc. Natl. Acad. Sci.
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