Keywords depression anxiety GABA alpha5 allosteric modulators Get full text access Log in, subscribe or purchase for full access. References 1. Ferrari, A.J. ∙ Charlson, F.J. ∙ Norman, R.E. ... The epidemiological modelling of major depressive disorder: application for the Global Burden of Disease Study 2010 PloS One. 2013; 8, e69637 2. Greenberg, P. ∙ Chitnis, A. ∙ Louie, D. ... The Economic Burden of Adults with Major Depressive Disorder in the United States (2019) Adv Ther. 2023; 40:4460-4479 4.