Muhammad Khairul Ramlee on Muck Rack

Muhammad Khairul Ramlee

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Articles

G-quadruplex homeostasis is a determinant of PARP inhibitor toxicity in BRCA2-deficient cells

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By Abhishek Sharma, Joanna Krwawicz, Arwa A. Abugable, Xin Zhen, Simran Khurana, Travis Stracker, Nicholas Lakin, Leandre Tappenden, Muhammad Khairul Ramlee
| Nature Verified
Abstract Inhibition of PARPs is a key strategy to treat tumours with defects in homologous recombination (HR), including those with mutations in the tumour suppressor gene BRCA2. PARP inhibitors generate replication stress, creating a dependence on HR to repair the resulting DNA damage. However, the DNA lesions generated upon PARP inhibition that impede replication fork progression and trigger a requirement for BRCA2 in cell survival are poorly defined.
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