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Abstract Proper orientation of the mitotic spindle is critical for a wide range of biological processes. However, the molecular mechanisms that regulate the formation of the spindle orientation machinery remain incompletely understood. In this study, we identify an essential role for ubiquitin-specific peptidase 21 (USP21)-mediated deubiquitylation in the control of spindle orientation.
1 Introduction Centrosomes are multifunctional, membrane-less organelles that play a crucial role in various cellular processes, including centriolar duplication, microtubule nucleation, ciliogenesis, cell division, and polarity formation [1-5]. The proper function of these processes depends on the accurate regulation and activity of centrosomal proteins.
1 Introduction Retinal degenerative diseases causing visual loss have become a major public health burden.[1] The retinal pigment epithelium (RPE) is a monolayer of regular polygonal cells occupying the outermost layer of the retina.
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