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Musan Yan on Muck Rack

Musan Yan

As seen in: Nature
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Articles

Angiotensin II exacerbates intracerebral hemorrhage in mice via heparin-like antithrombin activation and coagulation dysfunction

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By Shaoying Wang, Min Xue, Chuanfeng Liu, Mengmeng Wang, Qikai Yin, Shiping Lin, Wenshuo Li, Gan Wang, Ren Lai, Heyu Ni, Xiaopeng Tang, Musan Yan, Yuanjie Yin
| Nature Verified
Abstract Hypertension has paradoxical prothrombotic-hemorrhagic predisposition toward cerebral infarction and intracerebral hemorrhage (ICH), but the mechanism remains poorly understood. We observed Angiotensin II (Ang II) inhibited coagulation by activating antithrombin through heparin-like acceleration of antithrombin-thrombin interaction. Ang II allosterically modulates the 386-397 loop of antithrombin to enhance thrombin inhibition.
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