Qikai Yin

Abstract Hypertension has paradoxical prothrombotic-hemorrhagic predisposition toward cerebral infarction and intracerebral hemorrhage (ICH), but the mechanism remains poorly understood. We observed Angiotensin II (Ang II) inhibited coagulation by activating antithrombin through heparin-like acceleration of antithrombin-thrombin interaction. Ang II allosterically modulates the 386-397 loop of antithrombin to enhance thrombin inhibition.

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Yang L, Yuan Y, Yin Q, Li X, Kang X, Cui Q, et al. (2025) Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells. PLoS Negl Trop Dis 19(8): e0013466. https://doi.org/10.1371/journal.pntd.0013466 Editor: Richard A.

All ticks were homogenized, and the filtered supernatant was used for isolation tests. The viral strain YB_tick_2023_236, isolated from H. longicornis collected from Banshi village (130°38′E, 42°95′N) of Hunchun City, induced CPEs in both Vero and SW-13 cell lines following inoculation but not in BHK-21 or MDBK cells. (Fig. 1A). A marked increase in viral RNA levels was observed from 24 to 96 hpi in Vero and SW‐13 cells, although not in BHK-21 and MDBK cells (Fig. 1B).