Nada ahmed

Abstract Choroidal neovascularisation (CNV) is a hallmark of wet/neovascular age-related macular degeneration (wAMD), characterized by aberrant blood vessel growth from the choroid into the retina. Both pathological angiogenesis and inflammation contribute to disease progression. Here we show that analsysis of single-cell RNA sequencing of experimental CNV lesions revealed upregulation of Zeb1 in angiogenic endothelial cells (ECs).

1 Introduction The endothelium forms the inner lining of both blood and lymphatic vessels, resulting in an interface between the vessel contents (blood or lymph) and surrounding interstitial spaces. This position exposes endothelial cells (ECs) to a range of mechanical and biochemical stimuli, leading to the emergence of distinct functional specializations and dynamic EC phenotypes, including organ-specific, arterial, venous, proliferative, and activated states [1].

Abstract Lung cancer remains a global health challenge that is unavoidable. Despite the advances in lung cancer classification using deep learning models, the performance remains highly dependent on hyperparameter selection, whereas conventional grid or random search methods are often computationally inefficient in high-dimensional spaces.