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Chris Denning

As seen in: Nature, MDPI, Cell Press, Observador, Insider Media, Inside Time, International Tax Review, Finance Monthly, Investment Monitor
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Articles

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy

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By Maya Noureddine, Halina Mikolajek, Nathan Cowieson, Nikos Pinotsis, Paul Robinson, Charles Redwood, Siobhan Loughna, Chris Denning, Fiyaz Mohammed, Katja Gehmlich, Alexandre Slater
| Nature Verified
Abstract Hypertrophic cardiomyopathy (HCM) is a genetic disease associated with sudden cardiac death. Variants in alpha-actinin-2 (ACTN2), a Z-disc protein that anchors actin thin filaments have been implicated in HCM, yet their structural consequences remain poorly defined. Here, we characterise seventeen HCM-associated ACTN2 variants spanning multiple domains using an integrated and tiered workflow combining high-throughput assays, structural modelling and biophysical approaches.
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Loss of endothelial ZEB1 enhances neovascularisation during choroidal neovascularisation

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By Joseph L Horder, Kathryn Green, Joshua H. Bourne, Amy Lynch, Nada ahmed, Guillermo Diez-Pinel, Christopher Carroll, Claire Allen, Charles Cresswell, Poppy Harris, Isabela G. Ferreira, Diogo Mosqueira, Julie Rayes, Nigel P Mongan, JOhn King, John King, Chris Denning, Alan McIntyre, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, David Bates, Andrew V. Benest, Nicholas Beazley-Long, Zarah B. Tabrizi
| Nature Verified
Abstract Choroidal neovascularisation (CNV) is a hallmark of wet/neovascular age-related macular degeneration (wAMD), characterized by aberrant blood vessel growth from the choroid into the retina. Both pathological angiogenesis and inflammation contribute to disease progression. Here we show that analsysis of single-cell RNA sequencing of experimental CNV lesions revealed upregulation of Zeb1 in angiogenic endothelial cells (ECs).
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Efficient multi-lineage cardiovascular differentiation of human pluripotent stem cells in animal serum-free conditions

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By Nguyen Vo, Kelvin Chung, Aishah Nasir, Davor Pavlovic, Chris Denning
| Nature Verified
Abstract Human induced pluripotent stem cell (hiPSC) technologies offer human-relevant cardiac models for biomedical applications. However, workflows for differentiation of cardiac stromal cells and fabrication of engineered heart tissue (EHT) commonly rely on animal serum, contrary to growing policy demands to reduce use of these products.
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