Naeem M. Nadaf

Abstract In the expanding field of spatial genomics, numerous methods have emerged to decode biomolecules in intact tissue sections. Advanced techniques based on combinatorial decoding can resolve thousands of features in a reasonable time but are often constrained by either the prohibitive costs associated with commercial platforms or the complexity of developing custom instruments.

Abstract The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within individual anatomical structures remain incompletely known.

Abstract Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex tissues are constructed1,2,3,4,5,6. However, missing from these measurements is the ability to routinely and easily spatially localize these profiled cells.