Naël Osmani

Abstract Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironments is not fully understood. Here we report that the deformability of CTCs affects their haematogenous dissemination and identify mechanical phenotypes that favour metastatic extravasation.

Abstract The spread of metastases is a crucial process in which some questions remain unanswered. In this work, we focus on tumor cells circulating in the bloodstream, the so called Circulating Tumor Cells (CTCs). Our aim is to characterize their trajectories under the influence of hemodynamic and adhesion forces.

Abstract Metastatic spread is a crucial process in which some questions remain unanswered. In this work, we focus on tumor cells circulating in the bloodstream, so-called Circulating Tumor Cells (CTCs). We aim to characterize their trajectories under the influence of hemodynamic forces and adhesion forces resulting from interaction with an endothelial layer using existing in vitro measurements performed with a microfluidic device.